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Title: Oropharyngeal colonization by nontypeable Haemophilus influenzae among healthy children attending day care centers
Author: Puig Pitarch, Carmen
Martí Martí, Sara
Fleites, Ana
Trabazo, Rafael
Calatayud, Laura
Liñares Louzao, Josefina
Ardanuy Tisaire, María Carmen
Keywords: Infeccions en els infants
Malalties dels infants
Escoles bressol
Infection in children
Children's diseases
Bacillus (Bacteria)
Issue Date: Oct-2014
Publisher: Mary Ann Liebert, Inc.
Abstract: Haemophilus influenzae colonizes the upper respiratory tract and can spread causing otitis and sinusitis. This work aimed to study the oropharyngeal carriage rate in healthy <5-year-old children attending day care centers in Oviedo, Spain in two consecutive years (January to March 2004-2005). The carriage rate was 42% (400/960) and highly variable among centers (range, 12% to 83%). Isolates were mainly identified as nontypeable H. influenzae (NTHi, 99%). Epidemiologically, 127 different genotypes were identified by PFGE with a minimum of two genotypes per center. One hundred fourteen children (12%) were included in both studies and none of them harbored the same strain over a period of time. The isolates only showed resistance to cotrimoxazol and ampicillin, presenting a shift in the level of ampicillin reduced susceptibility, showing a predominance of PBP3 mutations in 2004 and a predominance of β-lactamase production in 2005. This study proved the great genetic variability of NTHi isolates that present similar genotypic patterns in both years with no long-term carriage of the same strain.
Note: Reproducció del document publicat a:
It is part of: Microbial Drug Resistance, 2014, vol. 20, num. 5, p. 450-455
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ISSN: 1076-6294
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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