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Title: Potential Role of Induced Pluripotent Stem Cells (IPSCs) for Cell-Based Therapy of the Ocular Surface
Author: Casaroli Marano, Ricardo Pedro
Nieto-Nicolau, N.
Martínez-Conesa, E.M.
Edel, Michael John
Álvarez Palomo, Ana Belén
Keywords: Cèl·lules mare embrionàries
Teràpia cel·lular
Embryonic stem cells
Cellular therapy
Issue Date: 12-Feb-2015
Publisher: MDPI
Abstract: The integrity and normal function of the corneal epithelium are crucial for maintaining the cornea's transparency and vision. The existence of a cell population with progenitor characteristics in the limbus maintains a dynamic of constant epithelial repair and renewal. Currently, cell-based therapies for bio replacement cultured limbal epithelial transplantation (CLET) and cultured oral mucosal epithelial transplantation (COMET) present very encouraging clinical results for treating limbal stem cell deficiency (LSCD) and restoring vision. Another emerging therapeutic approach consists of obtaining and implementing human progenitor cells of different origins in association with tissue engineering methods. The development of cell-based therapies using stem cells, such as human adult mesenchymal or induced pluripotent stem cells (IPSCs), represent a significant breakthrough in the treatment of certain eye diseases, offering a more rational, less invasive, and better physiological treatment option in regenerative medicine for the ocular surface. This review will focus on the main concepts of cell-based therapies for the ocular surface and the future use of IPSCs to treat LSCD.
Note: Reproducció del document publicat a:
It is part of: Journal of Clinical Medicine, 2015, vol. 4, num. 2, p. 318-342
Related resource:
ISSN: 2077-0383
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)

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