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Title: Longitudinal liver stiffness assessment in patient with chronic hepatitis C undergoing antiviral therapy.
Author: Martínez, Stella M.
Foucher, Juliette
Combis, Jean Marc
Métivier, Sophie
Brunetto, Maurizia
Capron, Dominique
Bourlière, Marc
Bonowicki, Jean Pierre
Dao, Thong
Maynard-Met, Marianne
Lucidarme, Damien
Merrouch, Wasil
Forns, Xavier
Lédinghen, Victor de
Keywords: Hepatitis C
Medicaments antivírics
Assaigs clínics
Hepatitis C
Antiviral agents
Clinical trials
Issue Date: 17-Oct-2012
Publisher: Public Library of Science (PLoS)
Abstract: BACKGROUND/AIMS:Liver stiffness (LS) measurement by means of transient elastography (TE) is accurate to predict fibrosis stage. The effect of antiviral treatment and virologic response on LS was assessed and compared with untreated patients with chronic hepatitis C (CHC). METHODS: TE was performed at baseline, and at weeks 24, 48, and 72 in 515 patients with CHC. RESULTS: 323 treated (62.7%) and 192 untreated patients (37.3%) were assessed. LS experienced a significant decline in treated patients and remained stable in untreated patients at the end of study (P<0.0001). The decline was significant for patients with baseline LS ≥ 7.1 kPa (P<0.0001 and P 0.03, for LS ≥ 9.5 and ≥ 7.1 kPa vs lower values, respectively). Sustained virological responders and relapsers had a significant LS improvement whereas a trend was observed in nonresponders (mean percent change -16%, -10% and -2%, for SVR, RR and NR, respectively, P 0.03 for SVR vs NR). In multivariate analysis, high baseline LS (P<0.0001) and ALT levels, antiviral therapy and non-1 genotype were independent predictors of LS improvement. CONCLUSIONS: LS decreases during and after antiviral treatment in patients with CHC. The decrease is significant in sustained responders and relapsers (particularly in those with high baseline LS) and suggests an improvement in liver damage.
Note: Reproducció del document publicat a:
It is part of: PLoS One, 2012, vol. 7, num. 10, p. e47715
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Medicina)

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