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Title: Involvement of PrP(C) in kainate-induced excitotoxicity in several mouse strains.
Author: Carulla Martí, Patricia
Llorens Torres, Franc
Matamoros-Anglès, Andreu
Aguilar-Calvo, Patricia
Espinosa, Juan Carlos
Gavín Marín, Rosalina
Ferrer, Isidro (Ferrer Abizanda)
Legname, Giuseppe
Torres, Juan Maria
Río Fernández, José Antonio del
Keywords: Malalties del sistema nerviós
Nervous system diseases
Issue Date: 9-Jul-2015
Publisher: Nature Publishing Group
Abstract: The cellular prion protein (PrPC) has been associated with a plethora of cellular functions ranging from cell cycle to neuroprotection. Mice lacking PrPC show an increased susceptibility to epileptic seizures; the protein, then, is neuroprotective. However, lack of experimental reproducibility has led to considering the possibility that other factors besides PrPC deletion, such as the genetic background of mice or the presence of so-called "Prnp flanking genes", might contribute to the reported susceptibility. Here, we performed a comparative analysis of seizure-susceptibility using characterized Prnp+/+ and Prnp0/0 mice of B6129, B6.129, 129/Ola or FVB/N genetic backgrounds. Our study indicates that PrPC plays a role in neuroprotection in KA-treated cells and mice. For this function, PrPC should contain the aa32<br>93 region and needs to be linked to the membrane. In addition, some unidentified "Prnp-flanking genes" play a role parallel to PrPC in the KA-mediated responses in B6129 and B6.129 Prnp0/0 mice.
Note: Reproducció del document publicat a:
It is part of: Scientific Reports, 2015, vol. 5, num. 11971
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

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