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Title: Clinical and molecular epidemiology of haemophilus influenzae causing invasive disease in adult patients
Author: Puig Pitarch, Carmen
Grau, Immaculada
Martí Martí, Sara
Tubau, Fe
Calatayud, Laura
Pallarés Giner, Roman
Liñares Louzao, Josefina
Ardanuy Tisaire, María Carmen
Keywords: Epidemiologia molecular
Malalties de l'aparell respiratori
Molecular epidemiology
Respiratory diseases
Issue Date: 7-Nov-2014
Publisher: Public Library of Science (PLoS)
Abstract: Objectives The epidemiology of invasive Haemophilus influenzae (Hi) has changed since the introduction of the Hi type b (Hib) vaccine. The aim of this study was to analyze the clinical and molecular epidemiology of Hi invasive disease in adults. Methods Clinical data of the 82 patients with Hi invasive infections were analyzed. Antimicrobial susceptibility, serotyping, and genotyping were studied (2008<br>2013). Results Men accounted for 63.4% of patients (whose mean age was 64.3 years). The most frequent comorbidities were immunosuppressive therapy (34.1%), malignancy (31.7%), diabetes, and COPD (both 22%). The 30-day mortality rate was 20.7%. The majority of the strains (84.3%) were nontypeable (NTHi) and serotype f was the most prevalent serotype in the capsulated strains. The highest antimicrobial resistance was for cotrimoxazole (27.1%) and ampicillin (14.3%). Twenty-three isolates (32.9%) had amino acid changes in the PBP3 involved in resistance. Capsulated strains were clonal and belonged to clonal complexes 6 (serotype b), 124 (serotype f), and 18 (serotype e), whereas NTHi were genetically diverse. Conclusions Invasive Hi disease occurred mainly in elderly and those with underlying conditions, and it was associated with a high mortality rate. NTHi were the most common cause of invasive disease and showed high genetic diversity.
Note: Reproducció del document publicat a:
It is part of: PLoS One, 2014, vol. 9, num. 11, p. e112711
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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