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Title: Zebrafish as a model for developmental toxicity assessment
Author: Teixidó Condomines, Elisabet
Piqué Benages, Maria Esther
Boix Sabrià, Núria
Llobet Mallafré, Joan M. (Joan Maria)
Gómez Catalán, Jesús
Keywords: Peix zebra
Zebra fish
Issue Date: 2015
Publisher: Research Signpost
Abstract: The zebrafish embryo has emerged as promising alternative model for traditional in vivo developmental toxicological screening due to their advantageous characteristics as their small size and transparency. In this paper, we reviewed the applicability of the zebrafish embryo model in some relevant areas to human t oxicology as developmental toxicity, cardiovascular toxicity and neurotoxicity (behavioral assessment). Despite the promising results, further optimization and testing of more substances as well as a harmonized methodology is needed to streamline the metho ds and make the assay conducive to medium - throughput.
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It is part of: Recent Advances in Pharmaceutical Sciences V, 2015, Research Signpost. Editors: Diego Muñoz Torrero, M. Pilar Vinardell & Javier Palazón. ISBN: 978-81-308-0561-0. Chapter 5, p. 65-83.
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Appears in Collections:Llibres / Capítols de llibre (Farmacologia, Toxicologia i Química Terapèutica)

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