Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/67718
Title: Potential signals of natural selection in the top risk loci for coronary artery disease: 9p21 and 10q11
Author: Zanetti, D.
Carreras-Torres, R.
Esteban i Torné, Maria Esther
Via i García, Marc
Moral Castrillo, Pedro
Keywords: Malalties coronàries
Factors de risc en les malalties
Selecció natural
Coronary diseases
Risk factors in diseases
Natural selection
Issue Date: 7-Aug-2015
Publisher: Public Library of Science (PLoS)
Abstract: Background: Coronary artery disease (CAD) is a complex disease and the leading cause of death in the world. Populations of different ancestry do not always share the same risk markers. Natural selective processes may be the cause of some of the population differences detected for specific risk mutations. Objective: In this study, 384 single nucleotide polymorphisms (SNPs) located in four genomic regions associated with CAD (1p13, 1q41, 9p21 and 10q11) are analysed in a set of 19 populations from Europe, Middle East and North Africa and also in Asian and African samples from the 1000 Genomes Project. The aim of this survey is to explore for the first time whether the genetic variability in these genomic regions is better explained by demography or by natural selection. Results: The results indicate significant differences in the structure of genetic variation and in the LD patterns among populations that probably explain the population disparities found in markers of susceptibility to CAD. Conclusions: The results are consistent with potential signature of positive selection in the 9p21 region and of balancing selection in the 9p21 and 10q11. Specifically, in Europe three CAD risk markers in the 9p21 region (rs9632884, rs1537371 and rs1333042) show consistent signals of positive selection. The results of this study are consistent with a potential selective role of CAD in the configuration of genetic diversity in current human populations.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0134840
It is part of: PLoS One, 2015, vol. 10, num. 8, p. e0134840
Related resource: http://dx.doi.org/10.1371/journal.pone.0134840
URI: http://hdl.handle.net/2445/67718
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Psicologia Clínica i Psicobiologia)

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