Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/67721
Title: The effect of potential supramolecular-bond promoters on the DNA-interacting abilities of copper-terpyridine compounds.
Author: Grau, Jordi
Brissos, Rosa F.
Salinas-Uber, Jorge
Caballero, Ana B.
Caubet Marín, Amparo
Roubeau, Olivier
Korrodi-Gregório, Luís
Pérez Tomás, Ricardo E.
Gámez Enamorado, Patrick
Keywords: Coure
Lligands
Mort cel·lular
Càncer
Compostos de metalls de transició
Copper
Ligands
Cell death
Cancer
Issue Date: 3-Aug-2015
Publisher: Royal Society of Chemistry
Abstract: Three copper(II) coordination compounds have been prepared from three different 2,2′:6′,2′′-terpyridine-based ligands, which have been selected to investigate the potential role of supramolecular interactions on the DNA-interacting and cytotoxicity properties of the corresponding metal complexes. Hence, the ligands 4′-((naphthalen-2-yl)methoxy)-2,2′:6′,2′′-terpyridine (Naphtpy) and 4′-((1H-benzo[d]imidazol-2-yl)methoxy)-2,2′:6′,2′′-terpyridine (Bimztpy) have been synthesized from commercially-available 4′-chloro-2,2′:6′,2′′-terpyridine (Cltpy), and their copper(II) complexes have been obtained by reaction with copper(II) nitrate. The DNA-interacting abilities of the corresponding compounds [Cu(Cltpy)(H2O)(NO3)2] (1), [Cu(naphtpy)(NO3)(H2O)](NO3)(MeOH) (2) and [Cu(bimztpy)(NO3)(H2O)](NO3) (3) have been investigated using different techniques, and cytotoxicity assays with several cancer cell lines have revealed interesting features, viz. the more efficient complex is 2, which although it does not act as a DNA cleaver, displays the most effective DNA-interacting and cytotoxic properties, compared to 1 and 3.
Note: Versió postprint del document publicat a: http://dx.doi.org/10.1039/c5dt02211h
It is part of: Dalton Transactions, 2015, vol. 44, p. 16061-16072
Related resource: http://dx.doi.org/10.1039/c5dt02211h
URI: http://hdl.handle.net/2445/67721
ISSN: 1477-9226
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

Files in This Item:
File Description SizeFormat 
653985.pdf2.63 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.