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DC Field | Value | Language |
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dc.contributor.author | Portillo, Karina | - |
dc.contributor.author | Torralba, Yolanda | - |
dc.contributor.author | Blanco Vich, Isabel | - |
dc.contributor.author | Burgos, Felip | - |
dc.contributor.author | Rodríguez-Roisin, Robert | - |
dc.contributor.author | Ríos, José | - |
dc.contributor.author | Roca Torrent, Josep | - |
dc.contributor.author | Barberà i Mir, Joan Albert | - |
dc.date.accessioned | 2015-11-17T10:53:55Z | - |
dc.date.available | 2015-11-17T10:53:55Z | - |
dc.date.issued | 2015-07-14 | - |
dc.identifier.issn | 1176-9106 | - |
dc.identifier.uri | http://hdl.handle.net/2445/67820 | - |
dc.description.abstract | Introduction: Few data are available in regards to the prevalence of pulmonary hypertension (PH) in the broad spectrum of COPD. This study was aimed at assessing the prevalence of PH in a cohort of COPD patients across the severity of airflow limitation, and reporting the hemodynamic characteristics at rest and during exercise. Methods: We performed a retrospective analysis on COPD patients who underwent right-heart catheterization in our center with measurements obtained at rest (n=139) and during exercise (n=85). PH was defined as mean pulmonary artery pressure (mPAP) >/25 mmHg and pulmonary capillary wedge pressure <15 mmHg. Exercise-induced PH (EIPH) was defined by a ratio of ΔmPAP/Δcardiac output >3. Results: PH was present in 25 patients (18%). According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification, PH prevalence in GOLD 2 was 7% (3 patients); 25% (14 patients) in GOLD 3; and 22% (8 patients) in GOLD 4. Severe PH (mPAP >/35 mmHg) was identified in four patients (2.8%). Arterial partial oxygen pressure was the outcome most strongly associated with PH (r=-0.29, P<0.001). EIPH was observed in 60 patients (71%)and had a similar prevalence in both GOLD 2 and 3, and was present in all GOLD 4 patients. Patients with PH had lower cardiac index during exercise than patients without PH (5.0±1.2 versus 6.7±1.4 L/min/m2 ,respectively; P=0.001). Conclusion: PH has a similar prevalence in COPD patients with severe and very-severe airflow limitation, being associated with the presence of arterial hypoxemia. In contrast, EIPH is highly prevalent, even in moderate COPD, and might contribute to limiting exercise tolerance. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Dove Medical Press | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.2147/COPD.S78180 | - |
dc.relation.ispartof | International Journal of Chronic Obstructive Pulmonary Disease, 2015, vol. 10, p. 1313-1320 | - |
dc.relation.uri | http://dx.doi.org/10.2147/COPD.S78180 | - |
dc.rights | cc-by-nc (c) Portillo, K. et al., 2015 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Malalties pulmonars obstructives cròniques | - |
dc.subject.classification | Hipertensió pulmonar | - |
dc.subject.other | Chronic obstructive pulmonary diseases | - |
dc.subject.other | Pulmonary hypertension | - |
dc.title | Pulmonary hemodynamic profile in chronic obstructive pulmonary disease | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 654370 | - |
dc.date.updated | 2015-11-17T10:53:55Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26203238 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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