Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/68059
Title: Type-1 cannabinoid receptor activity during Alzheimer's disease progression 
Author: Manuel, Iván
González de San Román, Estíbaliz
Giralt, M. Teresa
Ferrer, Isidro (Ferrer Abizanda)
Rodríguez Puertas, Rafael
Keywords: Malaltia d'Alzheimer
Cànnabis
Proteïnes G
Fixació de proteïnes
Alzheimer's disease
Cannabis
G Proteins
Protein binding
Issue Date: 10-Oct-2014
Publisher: IOS Press
Abstract: The activity of CB1 cannabinoid receptors was studied in postmortem brain samples of Alzheimer's disease (AD) patients during clinical deterioration. CB1 activity was higher at earlier AD stages in limited hippocampal areas and internal layers of frontal cortex, but a decrease was observed at the advanced stages. The pattern of modification appears to indicate initial hyperactivity of the endocannabinoid system in brain areas that lack classical histopathological markers at earlier stages of AD, indicating an attempt to compensate for the initial synaptic impairment, which is then surpassed by disease progression. These results suggest that initial CB1 stimulation might have therapeutic relevance.
Note: Reproducció del document publicat a: http://dx.doi.org/10.3233/JAD-140492
It is part of: Journal of Alzheimer's Disease, 2014, vol. 42, num. 3, p. 761-766
Related resource: http://dx.doi.org/10.3233/JAD-140492
URI: http://hdl.handle.net/2445/68059
ISSN: 1387-2877
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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