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http://hdl.handle.net/2445/68435
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DC Field | Value | Language |
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dc.contributor.author | Couch, Robert B. | - |
dc.contributor.author | Bayas Rodríguez, José María | - |
dc.contributor.author | Caso, Covadonga | - |
dc.contributor.author | Mbawuike, Innocent Nnadi | - |
dc.contributor.author | Núñez López, Concepción | - |
dc.contributor.author | Claeys, Carine | - |
dc.contributor.author | El Idrissi, Mohamed | - |
dc.contributor.author | Herve, Caroline | - |
dc.contributor.author | Laupeze, Beatrice | - |
dc.contributor.author | Oostvogels, Lidia | - |
dc.contributor.author | Moris, Philippe | - |
dc.date.accessioned | 2015-12-14T13:19:59Z | - |
dc.date.available | 2015-12-14T13:19:59Z | - |
dc.date.issued | 2014-07-30 | - |
dc.identifier.issn | 1471-2334 | - |
dc.identifier.uri | http://hdl.handle.net/2445/68435 | - |
dc.description.abstract | BACKGROUND: The effectiveness of trivalent influenza vaccines may be reduced in older versus younger adults because of age-related immunosenescence. The use of an adjuvant in such a vaccine is one strategy that may combat immunosenescence, potentially by bolstering T-cell mediated responses. METHODS: This observer-blind study, conducted in the United States (US) and Spain during the 2008-2009 influenza season, evaluated the effect of Adjuvant System AS03 on specific T-cell responses to a seasonal trivalent influenza vaccine (TIV) in >/=65 year-old adults.Medically-stable adults aged >/=65 years were randomly allocated to receive a single dose of AS03-adjuvanted TIV (TIV/AS03) or TIV. Healthy adults aged 18-40 years received only TIV. Blood samples were collected on Day 0, Day 21, Day 42 and Day 180. Influenza-specific CD4+ T cells, defined by the induction of the immune markers CD40L, IL-2, IFN-gamma, or TNF-alpha, were measured in ex vivo cultures of antigen-stimulated peripheral blood mononuclear cells. RESULTS: A total of 192 adults were vaccinated: sixty nine and seventy three >/=65 year olds received TIV/AS03 and TIV, respectively; and fifty 18 - 40 year olds received TIV. In the >/=65 year-old group on Day 21, the frequency of CD4+ T cells specific to the three vaccine strains was superior in the TIV/AS03 recipients to the frequency in TIV (p < 0.001). On Days 42 and 180, the adjusted-geometric mean specific CD4+ T-cell frequencies were also higher in the TIV/AS03 recipients than in the TIV recipients (p < 0.001). Furthermore, the adjusted-geometric mean specific CD4+ T-cell frequencies were higher in the >/=65 year-old recipients of TIV/AS03 than in the 18 - 40 year old recipients of TIV on Days 21 (p = 0.006) and 42 (p = 0.011). CONCLUSION: This positive effect of AS03 Adjuvant System on the CD4+ T-cell response to influenza vaccine strains in older adults could confer benefit in protection against clinical influenza disease in this population. TRIAL REGISTRATION: (Clinicaltrials.gov.). NCT00765076. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1186/1471-2334-14-425 | - |
dc.relation.ispartof | BMC Infectious Diseases, 2014, num. 14, p. 425 | - |
dc.relation.uri | http://dx.doi.org/10.1186/1471-2334-14-425 | - |
dc.rights | cc by (c) Couch et al., 2014 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | - |
dc.source | Articles publicats en revistes (ISGlobal) | - |
dc.subject.classification | Grip | - |
dc.subject.classification | Vacunació | - |
dc.subject.classification | Persones grans | - |
dc.subject.classification | Assaigs clínics | - |
dc.subject.other | Influenza | - |
dc.subject.other | Vaccination | - |
dc.subject.other | Older people | - |
dc.subject.other | Clinical trials | - |
dc.title | Superior antigen-specific CD4+ T-cell response with AS03-adjuvantation of a trivalent influenza vaccine in a randomised trial of adults aged 65 and older | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2015-12-04T15:27:49Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25078387 | - |
dc.identifier.pmid | 30574167 | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
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File | Description | Size | Format | |
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couch2014_1799.pdf | 1.93 MB | Adobe PDF | View/Open |
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