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http://hdl.handle.net/2445/68592
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DC Field | Value | Language |
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dc.contributor.author | Rubio, Mar | - |
dc.contributor.author | López Arnau, Raúl | - |
dc.contributor.author | Pubill Sánchez, David | - |
dc.contributor.author | Escubedo Rafa, Elena | - |
dc.contributor.author | Camarasa García, Jordi | - |
dc.date.accessioned | 2015-12-23T18:06:44Z | - |
dc.date.available | 2016-01-31T23:01:41Z | - |
dc.date.issued | 2015-01-29 | - |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.uri | http://hdl.handle.net/2445/68592 | - |
dc.description.abstract | 4-Methylamphetamine (4-MA) has recently emerged as a designer drug of abuse in Europe and it is consumed always with amphetamine. There have been reported some deaths and non-fatal intoxications related to 4-MA. We investigated the changes in locomotor activity and body temperature after 4-MA administration to male Sprague-Dawley rats. Our experiments were carried out at a normal or high ambient temperature. 4-MA (2.5-10 mg/Kg, given subcutaneously) increased, in a dose-dependent manner, the horizontal locomotor activity that was significantly reduced by ketanserin, p-cholorophenylalanine (pCPA) or haloperidol, but not by pindolol. In addition, we have studied the effect of 4-MA on core body temperature by means of an implanted electronic thermograph, enabling continuous measurement of body temperature. We observed a dose-dependent hypothermic response to 4-MA that reached a maximum 45 min after a single injection. We also evidenced slight tachyphylaxis to the hypothermic effect when 4-MA was administered four times in a 2 h interval. The pre-treatment of animals with pCPA or pindolol, but not with ketanserin, fully abolished the hypothermic effect of 4-MA. With all that, we conclude that hypothermia induced by 4-MA is due to the release of 5-HT which activates postsynaptic 5-HT1A receptors. | - |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isformatof | Versió postprint del document publicat a: http://dx.doi.org/10.1016/j.neulet.2015.01.075 | - |
dc.relation.ispartof | Neuroscience Letters, 2015, vol. 590, p. 68-73 | - |
dc.relation.uri | http://dx.doi.org/10.1016/j.neulet.2015.01.075 | - |
dc.rights | (c) Elsevier B.V., 2015 | - |
dc.source | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) | - |
dc.subject.classification | Amfetamines | - |
dc.subject.classification | Farmacologia | - |
dc.subject.classification | Hipotèrmia | - |
dc.subject.classification | Sistema nerviós central | - |
dc.subject.classification | Serotonina | - |
dc.subject.other | Amphetamines | - |
dc.subject.other | Pharmacology | - |
dc.subject.other | Hypothermia | - |
dc.subject.other | Central nervous system | - |
dc.subject.other | Serotonin | - |
dc.title | Serotonin is involved in the psychostimulant and hypothermic effect of 4-methylamphetamine in rats. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 648986 | - |
dc.date.updated | 2015-12-23T18:06:44Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25641130 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Biomedicina (IBUB)) Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
Files in This Item:
File | Description | Size | Format | |
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648986.pdf | 813.29 kB | Adobe PDF | View/Open |
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