Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/69157
Title: BMP signaling in telencephalic neural cell specification and maturation
Author: Gamez Molina, Beatriz
Rodriguez-Carballo, Edgardo
Ventura Pujol, Francesc
Keywords: Morfogènesi
Transducció de senyal cel·lular
Sistema nerviós
Citoquines
Regulació cel·lular
Morphogenesis
Cellular signal transduction
Nervous system
Cytokines
Cellular control mechanisms
Issue Date: 4-Jun-2013
Publisher: Frontiers Media
Abstract: Bone morphogenetic proteins (BMPs) make up a family of morphogens that are critical for patterning, development, and function of the central and peripheral nervous system. Their effects on neural cells are pleiotropic and highly dynamic depending on the stage of development and the local niche. Neural cells display a broad expression profile of BMP ligands, receptors, and transducer molecules. Moreover, interactions of BMP signaling with other incoming morphogens and signaling pathways are crucial for most of these processes. The key role of BMP signaling suggests that it includes many regulatory mechanisms that restrict BMP activity both temporally and spatially. BMPs affect neural cell fate specification in a dynamic fashion. Initially they inhibit proliferation of neural precursors and promote the first steps in neuronal differentiation. Later on, BMP signaling effects switch from neuronal induction to promotion of astroglial identity and inhibition of neuronal or oligodendroglial lineage commitment. Furthermore, in postmitotic cells, BMPs regulate cell survival and death, to modulate neuronal subtype specification, promote dendritic and axonal growth and induce synapse formation and stabilization. In this review, we examine the canonical and non-canonical mechanisms of BMP signal transduction. Moreover, we focus on the specific role of BMPs in the nervous system including their ability to regulate neural stem cell proliferation, self-renewal, lineage specification, and neuronal function.
Note: Reproducció del document publicat a: http://dx.doi.org/10.3389/fncel.2013.00087
It is part of: Frontiers in Cellular Neuroscience, 2013, vol. 7, num. 87, p. 1-13
Related resource: http://dx.doi.org/10.3389/fncel.2013.00087
URI: http://hdl.handle.net/2445/69157
ISSN: 1662-5102
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Files in This Item:
File Description SizeFormat 
631185.pdf2.02 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons