Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/69166
Title: Robust and Reproducible Quantification of the Extent of Chest Radiographic Abnormalities (And It's Free!)
Author: Requena-Méndez, Ana
Aldasoro, Edelweiss
Muñoz, José
Moore, David A. J.
Keywords: Tuberculosi
Radiografia
Programari lliure
Processament d'imatges
Perú
Tuberculosis
Radiography
Open source software
Image processing
Peru
Issue Date: 21-May-2015
Publisher: Public Library of Science (PLoS)
Abstract: RATIONALE: Objective, reproducible quantification of the extent of abnormalities seen on a chest radiograph would improve the user-friendliness of a previously proposed severity scoring system for pulmonary tuberculosis and could be helpful in monitoring response to therapy, including in clinical trials. METHODS: In this study we report the development and evaluation of a simple tool using free image editing software (GIMP) to accurately and reproducibly quantify the area of affected lung on the chest radiograph of tuberculosis patients. As part of a pharmacokinetic study in Lima, Peru, a chest radiograph was performed on patients with pulmonary tuberculosis and this was subsequently photographed using a digital camera. The GIMP software was used by two independent and trained readers to estimate the extent of affected lung (expressed as a percentage of total lung area) in each radiograph and the resulting radiographic SCORE. RESULTS: 56 chest radiographs were included in the reading analysis. The Intraclass correlation coefficient (ICC) between the 2 observers was 0.977 (p<0.001) for the area of lung affected and was 0.955 (p<0.001) for the final score; and the kappa coefficient of Interobserver agreement for both the area of lung affected and the score were 0.9 (p<0.001) and 0.86 (p<0.001) respectively. CONCLUSIONS: This high level of between-observer agreement suggests that this freely available software could constitute a simple and useful tool for robust evaluation of individual and serial chest radiographs.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0128044
It is part of: PLoS One, 2015, vol. 10, num. 5, p. e0128044
Related resource: http://dx.doi.org/10.1371/journal.pone.0128044
URI: http://hdl.handle.net/2445/69166
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (ISGlobal)

Files in This Item:
File Description SizeFormat 
requena-mendez2015_1886.pdf3.79 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons