Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/69171
Title: Financial and Economic Costs of the Elimination and Eradication of Onchocerciasis (River Blindness) in Africa
Author: Kim, Young E.
Sicuri, Elisa
Tediosi, Fabrizio
Keywords: Malalties parasitàries
Epidemiologia
Àfrica subsahariana
Anàlisi econòmica
Oncocercosi
Parasitic diseases
Epidemiology
Sub-Saharan Africa
Economic analysis
Onchocerciasis
Issue Date: 11-Sep-2015
Publisher: Public Library of Science (PLoS)
Abstract: BACKGROUND: Onchocerciasis (river blindness) is a parasitic disease transmitted by blackflies. Symptoms include severe itching, skin lesions, and vision impairment including blindness. More than 99% of all cases are concentrated in sub-Saharan Africa. Fortunately, vector control and community-directed treatment with ivermectin have significantly decreased morbidity, and the treatment goal is shifting from control to elimination in Africa. METHODS: We estimated financial resources and societal opportunity costs associated with scaling up community-directed treatment with ivermectin and implementing surveillance and response systems in endemic African regions for alternative treatment goals-control, elimination, and eradication. We used a micro-costing approach that allows adjustment for time-variant resource utilization and for the heterogeneity in the demographic, epidemiological, and political situation. RESULTS: The elimination and eradication scenarios, which include scaling up treatments to hypo-endemic and operationally challenging areas at the latest by 2021 and implementing intensive surveillance, would allow savings of $1.5 billion and $1.6 billion over 2013-2045 as compared to the control scenario. Although the elimination and eradication scenarios would require higher surveillance costs ($215 million and $242 million) than the control scenario ($47 million), intensive surveillance would enable treatments to be safely stopped earlier, thereby saving unnecessary costs for prolonged treatments as in the control scenario lacking such surveillance and response systems. CONCLUSIONS: The elimination and eradication of onchocerciasis are predicted to allow substantial cost-savings in the long run. To realize cost-savings, policymakers should keep empowering community volunteers, and pharmaceutical companies would need to continue drug donation. To sustain high surveillance costs required for elimination and eradication, endemic countries would need to enhance their domestic funding capacity. Societal and political will would be critical to sustaining all of these efforts in the long term.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pntd.0004056
It is part of: PLoS Neglected Tropical Diseases, 2015, vol. 9, num. 9, p. e0004056
Related resource: http://dx.doi.org/10.1371/journal.pntd.0004056
URI: http://hdl.handle.net/2445/69171
ISSN: 1935-2727
Appears in Collections:Articles publicats en revistes (ISGlobal)

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