Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/69187
Title: Vitamin K-dependent proteins GAS6 and Protein S and TAM receptors in patients of systemic lupus erythematosus: correlation with common genetic variants and disease activity
Author: Recarte-Pelz, Pedro
Tàssies Penella, María Dolores
Espinosa Garriga, Gerard
Hurtado, Begoña
Sala, Núria
Cervera i Segura, Ricard, 1960-
Reverter Calatayud, Juan Carlos
García de Frutos, Pablo
Keywords: Lupus eritematós
Pèptids
Proteïnes quinases
Lupus erythematosus
Peptides
Protein kinases
Issue Date: 12-Mar-2013
Publisher: BioMed Central
Abstract: Introduction: Growth arrest-specific gene 6 protein (GAS6) and protein S (ProS) are vitamin K-dependent proteins present in plasma with important regulatory functions in systems of response and repair to damage. They interact with receptor tyrosine kinases of the Tyro3, Axl and MerTK receptor tyrosine kinase (TAM) family, involved in apoptotic cell clearance (efferocytosis) and regulation of the innate immunity. TAM-deficient mice show spontaneous lupus-like symptoms. Here we tested the genetic profile and plasma levels of components of the system in patients with systemic lupus erythematosus (SLE), and compare them with a control healthy population. Methods: Fifty SLE patients and 50 healthy controls with matched age, gender and from the same geographic area were compared. Genetic analysis was performed in GAS6 and the TAM receptor genes on SNPs previously identified. The concentrations of GAS6, total and free ProS, and the soluble forms of the three TAM receptors (sAxl, sMerTK and sTyro3) were measured in plasma from these samples. Results: Plasma concentrations of GAS6 were higher and, total and free ProS were lower in the SLE patients compared to controls, even when patients on oral anticoagulant treatment were discarded. Those parameters correlated with SLE disease activity index (SLEDAI) score, GAS6 being higher in the most severe cases, while free and total ProS were lower. All 3 soluble receptors increased its concentration in plasma of lupus patients. Conclusions: The present study highlights that the GAS6/ProS-TAM system correlates in several ways with disease activity in SLE. We show here that this correlation is affected by common polymorphisms in the genes of the system. These findings underscore the importance of mechanism of regulatory control of innate immunity in the pathology of SLE.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1186/ar4199
It is part of: Arthritis Research & Therapy, 2013, vol. 15, p. R41
Related resource: http://dx.doi.org/10.1186/ar4199
URI: http://hdl.handle.net/2445/69187
ISSN: 1478-6362
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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