Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/69200
Title: CB2 Cannabinoid Receptor Agonist Ameliorates Alzheimer-Like Phenotype in AβPP/PS1 Mice
Author: Asó, Ester
Juvés, Salvador
Maldonado, Rafael, 1961-
Ferrer, Isidro (Ferrer Abizanda)
Keywords: Malaltia d'Alzheimer
Cànnabis
Cognició
Estrès oxidatiu
Alzheimer's disease
Cannabis
Cognition
Oxidative stress
Issue Date: 1-Jun-2013
Publisher: IOS Press
Abstract: The specific CB2 cannabinoid receptor agonist JWH-133 induced cognitive improvement in double AβPP/PS1 transgenic mice, a genetic model of Alzheimer's disease. This effect was more pronounced when administered at the pre-symptomatic rather than the early symptomatic stage. The cognitive improvement was associated with decreased microglial reactivity and reduced expression of pro-inflammatory cytokines IL-1β, IL-6, TNFα, and IFNγ. In addition, JWH-133 reduced the expression of active p38 and SAPK/JNK, increased the expression of inactive GSK3β, and lowered tau hyperphosphorylation at Thr181 in the vicinity of amyloid-β plaques. Moreover, JWH-133 produced a decrease in the expression of hydroxynonenal adducts, and enhanced the expression of SOD1 and SOD2 around plaques. In contrast, the chronic treatment with JWH-133 failed to modify the amyloid-β production or deposition in cortex and hippocampus. In conclusion, the present study lends support to the idea that stimulation of CB2 receptors ameliorates several altered parameters in Alzheimer's disease such as impaired memory and learning, neuroinflammation, oxidative stress damage and oxidative stress responses, selected tau kinases, and tau hyperphosphorylation around plaques.
Note: Reproducció del document publicat a: http://dx.doi.org/10.3233/JAD-130137
It is part of: Journal of Alzheimer's Disease, 2013, vol. 35, num. 4, p. 847-858
Related resource: http://dx.doi.org/10.3233/JAD-130137
URI: http://hdl.handle.net/2445/69200
ISSN: 1387-2877
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Patologia i Terapèutica Experimental)

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