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|Title:||Malaria preventive therapy in pregnancy and its potential impact on immunity to malaria in an area of declining transmission|
Randall, Louise M.
Unger, Holger W.
Brown, Graham V.
Rogerson, Stephen J.
|Abstract:||BACKGROUND: Regular anti-malarial therapy in pregnancy, a pillar of malaria control, may affect malaria immunity, with therapeutic implications in regions of reducing transmission. METHODS: Plasma antibodies to leading vaccine candidate merozoite antigens and opsonizing antibodies to endothelial-binding and placental-binding infected erythrocytes were quantified in pregnant Melanesian women receiving sulfadoxine-pyrimethamine (SP) with chloroquine taken once, or three courses of SP with azithromycin. RESULTS: Malaria prevalence was low. Between enrolment and delivery, antibodies to recombinant antigens declined in both groups (p < 0.0001). In contrast, median levels of opsonizing antibodies did not change, although levels for some individuals changed significantly. In multivariate analysis, the malaria prevention regimen did not influence antibody levels. CONCLUSION: Different preventive anti-malarial chemotherapy regimens used during pregnancy had limited impact on malarial-immunity in a low-transmission region of Papua New Guinea. TRIAL REGISTRATIONS: NCT01136850.|
|Note:||Reproducció del document publicat a: http://dx.doi.org/10.1186/s12936-015-0736-x|
|It is part of:||Malaria Journal, 2015, vol. 14, num. 215, 8 p.|
|Appears in Collections:||Articles publicats en revistes (ISGlobal)|
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