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http://hdl.handle.net/2445/69241
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DC Field | Value | Language |
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dc.contributor.author | Teo, Andrew | - |
dc.contributor.author | Hasang, Wina | - |
dc.contributor.author | Randall, Louise M. | - |
dc.contributor.author | Unger, Holger Werner | - |
dc.contributor.author | Siba, Peter | - |
dc.contributor.author | Mueller, Ivo | - |
dc.contributor.author | Brown, Graham V. | - |
dc.contributor.author | Rogerson, Stephen John | - |
dc.date.accessioned | 2016-02-04T12:51:27Z | - |
dc.date.available | 2016-02-04T12:51:27Z | - |
dc.date.issued | 2015-05-26 | - |
dc.identifier.issn | 1475-2875 | - |
dc.identifier.uri | http://hdl.handle.net/2445/69241 | - |
dc.description.abstract | BACKGROUND: Regular anti-malarial therapy in pregnancy, a pillar of malaria control, may affect malaria immunity, with therapeutic implications in regions of reducing transmission. METHODS: Plasma antibodies to leading vaccine candidate merozoite antigens and opsonizing antibodies to endothelial-binding and placental-binding infected erythrocytes were quantified in pregnant Melanesian women receiving sulfadoxine-pyrimethamine (SP) with chloroquine taken once, or three courses of SP with azithromycin. RESULTS: Malaria prevalence was low. Between enrolment and delivery, antibodies to recombinant antigens declined in both groups (p < 0.0001). In contrast, median levels of opsonizing antibodies did not change, although levels for some individuals changed significantly. In multivariate analysis, the malaria prevention regimen did not influence antibody levels. CONCLUSION: Different preventive anti-malarial chemotherapy regimens used during pregnancy had limited impact on malarial-immunity in a low-transmission region of Papua New Guinea. TRIAL REGISTRATIONS: NCT01136850. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1186/s12936-015-0736-x | - |
dc.relation.ispartof | Malaria Journal, 2015, vol. 14, num. 215, 8 p. | - |
dc.relation.uri | http://dx.doi.org/10.1186/s12936-015-0736-x | - |
dc.rights | cc by (c) Teo et al., 2015 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | - |
dc.source | Articles publicats en revistes (ISGlobal) | - |
dc.subject.classification | Malària | - |
dc.subject.classification | Plasmodium falciparum | - |
dc.subject.classification | Immunitat | - |
dc.subject.classification | Embaràs | - |
dc.subject.other | Malaria | - |
dc.subject.other | Plasmodium falciparum | - |
dc.subject.other | Immunity | - |
dc.subject.other | Pregnancy | - |
dc.title | Malaria preventive therapy in pregnancy and its potential impact on immunity to malaria in an area of declining transmission | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2016-02-02T15:33:14Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26006260 | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
Files in This Item:
File | Description | Size | Format | |
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teo2015_1888.pdf | 469.79 kB | Adobe PDF | View/Open |
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