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Title: Proteins of Bartonella bacilliformis: Candidates for Vaccine Development
Author: Henriquez-Camacho, C.
Ventosilla, P.
Minnick, M.F.
Ruiz, Joaquim
Maguina, C.
Keywords: Malalties infeccioses
Bacteriologia mèdica
Amèrica del Sud
Communicable diseases
Medical bacteriology
South America
Issue Date: 6-Aug-2015
Publisher: Hindawi Publishing Corporation
Abstract: Bartonella bacilliformis is the etiologic agent of Carrion's disease or Oroya fever. B. bacilliformis infection represents an interesting model of human host specificity. The notable differences in clinical presentations of Carrion's disease suggest complex adaptations by the bacterium to the human host, with the overall objectives of persistence, maintenance of a reservoir state for vectorial transmission, and immune evasion. These events include a multitude of biochemical and genetic mechanisms involving both bacterial and host proteins. This review focuses on proteins involved in interactions between B. bacilliformis and the human host. Some of them (e.g., flagellin, Brps, IalB, FtsZ, Hbp/Pap31, and other outer membrane proteins) are potential protein antigen candidates for a synthetic vaccine.
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It is part of: International Journal of Peptides, 2015, vol. 2015, num. , p. 1-6
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ISSN: 1687-9767
Appears in Collections:Articles publicats en revistes (ISGlobal)

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