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DC Field | Value | Language |
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dc.contributor.author | Tagbor, Harry | - |
dc.contributor.author | Cairns, Matthew | - |
dc.contributor.author | Bojang, Kalifa | - |
dc.contributor.author | Coulibaly, Sheikh | - |
dc.contributor.author | Kayentao, Kassoum | - |
dc.contributor.author | Williams, John | - |
dc.contributor.author | Abubakar, Ismaela | - |
dc.contributor.author | Akor, Francis | - |
dc.contributor.author | Mohammed, Khalifa | - |
dc.contributor.author | Bationo, Richard | - |
dc.contributor.author | Dabira, Edgar | - |
dc.contributor.author | Soulama, Alamissa | - |
dc.contributor.author | Djimdé, Moussa | - |
dc.contributor.author | Guirou, Etienne | - |
dc.contributor.author | Awine, Timothy | - |
dc.contributor.author | Quaye, Stephen L. | - |
dc.contributor.author | Njie, Fanta | - |
dc.contributor.author | Ordi i Majà, Jaume | - |
dc.contributor.author | Doumbo, Ogobara | - |
dc.contributor.author | Hodgson, Abraham | - |
dc.contributor.author | Oduro, Abraham | - |
dc.contributor.author | Meshnick, Steven R. | - |
dc.contributor.author | Taylor, Steve | - |
dc.contributor.author | Magnussen, Pascal | - |
dc.contributor.author | Ter Kuile, Feiko O. | - |
dc.contributor.author | Woukeu, Arouna | - |
dc.contributor.author | Milligan, Paul | - |
dc.contributor.author | Chandramohan, Daniel | - |
dc.contributor.author | Greenwood, Brian | - |
dc.date.accessioned | 2016-02-04T13:36:38Z | - |
dc.date.available | 2016-02-04T13:36:38Z | - |
dc.date.issued | 2015-08-10 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/69255 | - |
dc.description.abstract | BACKGROUND: The efficacy of intermittent preventive treatment for malaria with sulfadoxine-pyrimethamine (IPTp-SP) in pregnancy is threatened in parts of Africa by the emergence and spread of resistance to SP. Intermittent screening with a rapid diagnostic test (RDT) and treatment of positive women (ISTp) is an alternative approach. METHODS AND FINDINGS: An open, individually randomized, non-inferiority trial of IPTp-SP versus ISTp was conducted in 5,354 primi- or secundigravidae in four West African countries with a low prevalence of resistance to SP (The Gambia, Mali, Burkina Faso and Ghana). Women in the IPTp-SP group received SP on two or three occasions whilst women in the ISTp group were screened two or three times with a RDT and treated if positive for malaria with artemether-lumefantrine (AL). ISTp-AL was non-inferior to IPTp-SP in preventing low birth weight (LBW), anemia and placental malaria, the primary trial endpoints. The prevalence of LBW was 15.1% and 15.6% in the IPTp-SP and ISTp-AL groups respectively (OR = 1.03 [95% CI: 0.88, 1.22]). The mean hemoglobin concentration at the last clinic attendance before delivery was 10.97g/dL and 10.94g/dL in the IPTp-SP and ISTp-AL groups respectively (mean difference: -0.03 g/dL [95% CI: -0.13, +0.06]). Active malaria infection of the placenta was found in 24.5% and in 24.2% of women in the IPTp-SP and ISTp-AL groups respectively (OR = 0.95 [95% CI 0.81, 1.12]). More women in the ISTp-AL than in the IPTp-SP group presented with malaria parasitemia between routine antenatal clinics (310 vs 182 episodes, rate difference: 49.4 per 1,000 pregnancies [95% CI 30.5, 68.3], but the number of hospital admissions for malaria was similar in the two groups. CONCLUSIONS: Despite low levels of resistance to SP in the study areas, ISTp-AL performed as well as IPTp-SP. In the absence of an effective alternative medication to SP for IPTp, ISTp-AL is a potential alternative to IPTp in areas where SP resistance is high. It may also have a role in areas where malaria transmission is low and for the prevention of malaria in HIV positive women receiving cotrimoxazole prophylaxis in whom SP is contraindicated. TRIAL REGISTRATION: ClinicalTrials.gov NCT01084213 Pan African Clinical trials Registry PACT201202000272122. | - |
dc.format.extent | 17 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0132247 | - |
dc.relation.ispartof | PLoS One, 2015, vol. 10, num. 8, p. e0132247 | - |
dc.relation.uri | http://dx.doi.org/10.1371/journal.pone.0132247 | - |
dc.rights | cc by (c) Tagbor et al., 2015 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | - |
dc.source | Articles publicats en revistes (Fonaments Clínics) | - |
dc.subject.classification | Assaigs clínics de medicaments | - |
dc.subject.classification | Malària | - |
dc.subject.classification | Complicacions en l'embaràs | - |
dc.subject.classification | Medicina preventiva | - |
dc.subject.other | Drug testing | - |
dc.subject.other | Malaria | - |
dc.subject.other | Complications of pregnancy | - |
dc.subject.other | Preventive medicine | - |
dc.title | A Non-Inferiority, Individually Randomized Trial of Intermittent Screening and Treatment versus Intermittent Preventive Treatment in the Control of Malaria in Pregnancy | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2016-02-02T15:35:25Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26258474 | - |
Appears in Collections: | Articles publicats en revistes (Fonaments Clínics) Articles publicats en revistes (ISGlobal) |
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