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Title: Rhodium-Catalyzed Pauson−Khand Reaction Using a Small-Bite-Angle P‑Stereogenic C1‑Diphosphine Ligand
Author: Cristóbal Lecina, Edgar
Costantino, Andrea R.
Grabulosa, Arnald
Riera i Escalé, Antoni
Verdaguer i Espaulella, Xavier
Keywords: Lligands
Catàlisi asimètrica
Reacció de Pauson-Khand
Enantioselective catalysis
Pauson-Khand reaction
Issue Date: 30-Sep-2015
Publisher: American Chemical Society
Abstract: The asymmetric Pauson−Khand reaction catalyzed by [Rh(COD)(MaxPHOS)]BF4 is described. Several 1,6-enynes have been chosen as model substrates affording moderate yields and selectivities of up to 86% ee. Besides binap-type ligands, we have demonstrated that the Pstereogenic C1-symmetry small-bite-angle ligand MaxPHOS is a viable ligand in this process. The formation of [2+2+2] cycloaddition compounds has shown to be a competitive process. A mechanism is proposed to account for the observed results. The intermediate rhodium dicarbonyl complex 6 was synthesized, and its solid-state structure was elucidated by X-ray crystallography.
Note: Reproducció del document publicat a:
It is part of: Organometallics, 2015, vol. 34, num. 20, p. 4989-4993
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ISSN: 0276-7333
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

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