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http://hdl.handle.net/2445/69372
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DC Field | Value | Language |
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dc.contributor.author | Teruel, María | - |
dc.contributor.author | McKinney, Cushla | - |
dc.contributor.author | Balsa, Alejandro | - |
dc.contributor.author | Pascual-Salcedo, Dora | - |
dc.contributor.author | Rodríguez-Rodríguez, Luis | - |
dc.contributor.author | Ortiz, Ana María | - |
dc.contributor.author | Gómez Vaquero, Carmen | - |
dc.contributor.author | González-Gay, Miguel A. | - |
dc.contributor.author | Smith, Malcolm | - |
dc.contributor.author | Witte, Torsten | - |
dc.contributor.author | Merriman, Tony | - |
dc.contributor.author | Lie, Benedicte A. | - |
dc.contributor.author | Martín, Javier | - |
dc.date.accessioned | 2016-02-10T18:01:39Z | - |
dc.date.available | 2016-02-10T18:01:39Z | - |
dc.date.issued | 2013-07-01 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/69372 | - |
dc.description.abstract | Given the role of CD247 in the response of the T cells, its entailment in autoimmune diseases and in order to better clarify the role of this gene in RA susceptibility, we aimed to analyze CD247 gene variants previously associated with other autoimmune diseases (rs1052237, rs2056626 and rs864537) in a large independent European Caucasian population. However, no evidence of association was found for the analyzed CD247 single-nucleotide polymorphisms (SNPs) with RA and with the presence/absence of anti-cyclic citrullinated polypeptide. We performed a meta-analysis including previously published GWAS data from the rs864537 variant, revealing an overall genome-wide significant association between this CD247 SNP and RA with anti-CCP (OR = 0.90, CI 95% = 0.87-0.93, Poverall = 2.1×10−10). Our results show for first time a GWAS-level association between this CD247 polymorphism and RA risk. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0068295 | - |
dc.relation.ispartof | PLoS One, 2013, vol. 8, num. 7, p. e68295 | - |
dc.relation.uri | http://dx.doi.org/10.1371/journal.pone.0068295 | - |
dc.rights | cc-by (c) Teruel, María et al., 2013 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Artritis reumatoide | - |
dc.subject.classification | Genoma humà | - |
dc.subject.classification | Malalties autoimmunitàries | - |
dc.subject.classification | Cèl·lules T | - |
dc.subject.other | Rheumatoid arthritis | - |
dc.subject.other | Human genome | - |
dc.subject.other | Autoimmune diseases | - |
dc.subject.other | T cells | - |
dc.title | Association of CD247 polymorphisms with rheumatoid arthritis: a replication study and a meta-analysis | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 649884 | - |
dc.date.updated | 2016-02-10T18:01:40Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 23861880 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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