Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/69386
Title: Polymorphisms in alcohol metabolism genes ADH1B and ALDH2, alcohol consumption and colorectal cancer
Author: Crous Bou, Marta
Rennert, Gad
Cuadras, Daniel
Salazar Soler, Ramón
Cordero Romera, David
Saltz Rennert, Hedy
Lejbkowicz, Flavio
Kopelovich, Levy
Monroe Lipkin, Steven
Bernard Gruber, Stephen
Moreno Aguado, Víctor
Keywords: Càncer colorectal
Consum d'alcohol
Deshidrogenases
Colorectal cancer
Drinking of alcoholic beverages
Dehydrogenases
Issue Date: 25-Nov-2013
Publisher: Public Library of Science (PLoS)
Abstract: Background: Colorectal cancer (CRC) is a leading cause of cancer death worldwide. Epidemiological risk factors for CRC included alcohol intake, which is mainly metabolized to acetaldehyde by alcohol dehydrogenase and further oxidized to acetate by aldehyde dehydrogenase; consequently, the role of genes in the alcohol metabolism pathways is of particular interest. The aim of this study is to analyze the association between SNPs in ADH1B and ALDH2 genes and CRC risk, and also the main effect of alcohol consumption on CRC risk in the study population. Methodology/Principal Findings: SNPs from ADH1B and ALDH2 genes, included in alcohol metabolism pathway, were genotyped in 1694 CRC cases and 1851 matched controls from the Molecular Epidemiology of Colorectal Cancer study. Information on clinicopathological characteristics, lifestyle and dietary habits were also obtained. Logistic regression and association analysis were conducted. A positive association between alcohol consumption and CRC risk was observed in male participants from the Molecular Epidemiology of Colorectal Cancer study (MECC) study (OR = 1.47; 95%CI = 1.18-1.81). Moreover, the SNPs rs1229984 in ADH1B gene was found to be associated with CRC risk: under the recessive model, the OR was 1.75 for A/A genotype (95%CI = 1.21-2.52; p-value = 0.0025). A path analysis based on structural equation modeling showed a direct effect of ADH1B gene polymorphisms on colorectal carcinogenesis and also an indirect effect mediated through alcohol consumption. Conclusions/Significance: Genetic polymorphisms in the alcohol metabolism pathways have a potential role in colorectal carcinogenesis, probably due to the differences in the ethanol metabolism and acetaldehyde oxidation of these enzyme variants.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0080158
It is part of: PLoS One, 2013, vol. 8, num. 11, p. e80158
Related resource: http://dx.doi.org/10.1371/journal.pone.0080158
URI: http://hdl.handle.net/2445/69386
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)

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