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Title: Perturbation of the dimer interface of triosephosphate isomerase and its effect on trypanosoma cruzi
Author: Olivares-Illana, Vanesa
Rodríguez-Romero, Adela
Becker, Ingeborg
Berzunza, Miriam
García, Juventino
Pérez-Montfort, Ruy
Cabrera, Nallely
López Calahorra, Francisco
Tuena de Gómez Puyou, Marieta
Gómez-Puyou, Armando
Keywords: Malaltia de Chagas
Chagas' disease
Issue Date: 31-Oct-2007
Publisher: Public Library of Science (PLoS)
Abstract: Chagas disease affects around 18 million people in the American continent. Unfortunately, there is no satisfactory treatment for the disease. The drugs currently used are not specific and exert serious toxic effects. Thus, there is an urgent need for drugs that are effective. Looking for molecules to eliminate the parasite, we have targeted a central enzyme of the glycolytic pathway: triosephosphate isomerase (TIM). The homodimeric enzyme is catalytically active only as a dimer. Because there are significant differences in the interface of the enzymes from the parasite and humans, we searched for small molecules that specifically disrupt contact between the two subunits of the enzyme from Trypanosoma cruzi but not those of TIM from Homo sapiens (HTIM), and tested if they kill the parasite.
Note: Reproducció del document publicat a:
It is part of: PLoS Neglected Tropical Diseases, 2007, vol. 1, num. 1, p. 50-57
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ISSN: 1935-2735
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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