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Title: Generation of magnetized olfactory ensheathing cells for regenerative studies in the central and peripheral nervous tissue
Author: Riggio, Cristina
Nocentini, Sara
Catalayud, María Pilar
Goya, Gerardo Fabian
Cuschieri, A. (Alfred), 1938-
Raffa, Vittoria
Río Fernández, José Antonio del
Keywords: Regeneració del sistema nerviós
Medul·la espinal
Nervous system regeneration
Spinal cord
Issue Date: 24-May-2013
Publisher: MDPI
Abstract: As olfactory receptor axons grow from the peripheral to the central nervous system (CNS) aided by olfactory ensheathing cells (OECs), the transplantation of OECs has been suggested as a plausible therapy for spinal cord lesions. The problem with this hypothesis is that OECs do not represent a single homogeneous entity, but, instead, a functionally heterogeneous population that exhibits a variety of responses, including adhesion and repulsion during cell-matrix interactions. Some studies report that the migratory properties of OECs are compromised by inhibitory molecules and potentiated by chemical gradients. In this paper, we report a system based on modified OECs carrying magnetic nanoparticles as a proof of concept experiment enabling specific studies aimed at exploring the potential of OECs in the treatment of spinal cord injuries. Our studies have confirmed that magnetized OECs (i) survive well without exhibiting stress-associated cellular responses; (ii) in vitro, their migration can be modulated by magnetic fields; and (iii) their transplantation in organotypic slices of spinal cord and peripheral nerve showed positive integration in the model. Altogether, these findings indicate the therapeutic potential of magnetized OECs for CNS injuries.
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It is part of: International Journal of Molecular Sciences, 2013, vol. 14, num. 6, p. 10852-10868
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ISSN: 1422-0067
Appears in Collections:Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

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