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Title: Robustness and stability of the gene regulatory network involved in DV boundary formation in the Drosophila wing
Author: Buceta Fernández, Javier
Herranz, Héctor
Canela Xandri, Oriol
Reigada Sanz, Ramon
Sagués i Mestre, Francesc
Milán, Marco
Keywords: Drosòfila
Issue Date: 11-Jul-2007
Publisher: Public Library of Science (PLoS)
Abstract: Gene regulatory networks have been conserved during evolution. The Drosophila wing and the vertebrate hindbrain share the gene network involved in the establishment of the boundary between dorsal and ventral compartments in the wing and adjacent rhombomeres in the hindbrain. A positive feedback-loop between boundary and non-boundary cells and mediated by the activities of Notch and Wingless/Wnt-1 leads to the establishment of a Notch dependent organizer at the boundary. By means of a Systems Biology approach that combines mathematical modeling and both in silico and in vivo experiments in the Drosophila wing primordium, we modeled and tested this regulatory network and present evidence that a novel property, namely refractoriness to the Wingless signaling molecule, is required in boundary cells for the formation of a stable dorsal-ventral boundary. This new property has been validated in vivo, promotes mutually exclusive domains of Notch and Wingless activities and confers stability to the dorsal-ventral boundary. A robustness analysis of the regulatory network complements our results and ensures its biological plausibility.
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It is part of: PLoS One, 2007, vol. 2, num. 7, p. e602
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Ciència dels Materials i Química Física)

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