Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/8042
Title: | Satisfaction survey with DNA cards method to collect genetic samples for pharmacogenetics studies |
Author: | Vidal Taboada, José Manuel Cucala, Mercedes Mas Herrero, Sergi Lafuente, Amàlia, 1952-2022 Cobos Carbó, Albert |
Keywords: | ADN Sang Farmacogenètica Investigació farmacèutica DNA analysis Blood Glutathione transferase |
Issue Date: | 2006 |
Publisher: | BioMed Central |
Abstract: | Background: Pharmacogenetic studies are essential in understanding the interindividual variability of drug responses. DNA sample collection for genotyping is a critical step in genetic studies. A method using dried blood samples from finger-puncture, collected on DNA-cards, has been described as an alternative to the usual venepuncture technique. The purpose of this study is to evaluate the implementation of the DNA cards method in a multicentre clinical trial, and to assess the degree of investigators' satisfaction and the acceptance of the patients perceived by the investigators.Methods: Blood samples were collected on DNA-cards. The quality and quantity of DNA recovered were analyzed. Investigators were questioned regarding their general interest, previous experience, safety issues, preferences and perceived patient satisfaction. Results: 151 patients' blood samples were collected. Genotyping of GST polymorphisms was achieved in all samples (100%). 28 investigators completed the survey. Investigators perceived patient satisfaction as very good (60.7%) or good (39.3%), without reluctance to finger puncture. Investigators preferred this method, which was considered safer and better than the usual methods. All investigators would recommend using it in future genetic studies. Conclusion: Within the clinical trial setting, the DNA-cards method was very well accepted by investigators and patients (in perception of investigators), and was preferred to conventional methods due to its ease of use and safety. |
Note: | Reproducció del document publicat a http://dx.doi.org/10.1186/1471-2350-7-45 |
It is part of: | BMC Medical Genetics, 2006, vol. 7, núm. 45 |
URI: | http://hdl.handle.net/2445/8042 |
Related resource: | http://dx.doi.org/10.1186/1471-2350-7-45 |
ISSN: | 1471-2350 |
Appears in Collections: | Articles publicats en revistes (Fonaments Clínics) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
543202.pdf | 473.45 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License