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|Title:||Tumor necrosis factor-alpha mediates changes in tissue protein turnover in a rat cancer cachexia model.|
Carbó Carbó, Neus
Bagby, Gregory J.
López-Soriano, Francisco J.
Argilés Huguet, Josep Ma.
Baccino, Francesco M.
Tumor necrosis factor
|Publisher:||American Society for Clinical Investigation|
|Abstract:||Rats bearing the Yoshida AH-130 ascites hepatoma showed enhanced fractional rates of protein degradation in gastrocnemius muscle, heart, and liver, while fractional synthesis rates were similar to those in non-tumor bearing rats. This hypercatabolic pattern was associated with marked perturbations of the hormonal homeostasis and presence of tumor necrosis factor in the circulation. The daily administration of a goat anti-murine TNF IgG to tumor-bearing rats decreased protein degradation rates in skeletal muscle, heart, and liver as compared with tumor-bearing rats receiving a nonimmune goat IgG. The anti-TNF treatment was also effective in attenuating early perturbations in insulin and corticosterone homeostasis. Although these results suggest that tumor necrosis factor plays a significant role in mediating the changes in protein turnover and hormone levels elicited by tumor growth, the inability of such treatment to prevent a reduction in body weight implies that other mediators or tumor-related events were also involved.|
|Note:||Reproducció del document publicat a http://dx.doi.org/doi:10.1172/JCI116897|
|It is part of:||Journal of Clinical Investigation, 1993, vol. 92, núm. 6, p. 2783-2789.|
|Appears in Collections:||Articles publicats en revistes (Bioquímica i Biomedicina Molecular)|
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