Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/96004
Title: A randomized placebo-controlled trial of intermittent preventive treatment in pregnant women in the context of insecticide treated nets delivered through the antenatal clinic
Author: Menéndez, Clara
Bardají, Azucena
Sigauque, Betuel
Romagosa Pérez-Portabella, Cleofé
Sanz, Sergi
Serra-Casas, Elisa
Macete, Eusébio
Berenguera, Anna
David, Catarina
Dobaño, Carlota, 1969-
Naniche, Denise
Mayor Aparicio, Alfredo Gabriel
Ordi i Majà, Jaume
Mandomando, Inacio
Aponte, John J.
Mabunda, Samuel
Alonso, Pedro
Keywords: Embarassades
Malària
Placebos
Assaigs clínics
Àfrica subsahariana
Pregnant women
Malaria
Placebos (Medicine)
Clinical trials
Sub-Saharan Africa
Issue Date: 9-Apr-2008
Publisher: Public Library of Science (PLoS)
Abstract: Background:Current recommendations to prevent malaria in African pregnant women rely on insecticide treated nets(ITNs) and intermittent preventive treatment (IPTp). However, there is no information on the safety and efficacy of theircombined use.Methods:1030 pregnant Mozambican women of all gravidities received a long-lasting ITN during antenatal clinic (ANC)visits and, irrespective of HIV status, were enrolled in a randomised, double blind, placebo-controlled trial, to assess thesafety and efficacy of 2-dose sulphadoxine-pyrimethamine (SP). The main outcome was the reduction in low birth weight.Findings:Two-dose SP was safe and well tolerated, but was not associated with reductions in anaemia prevalence atdelivery (RR, 0.92 [95% CI, 0.79-1.08]), low birth weight (RR, 0.99 [95% CI, 0.70-1.39]), or overall placental infection(p = 0.964). However, the SP group showed a 40% reduction (95% CI, 7.40-61.20]; p = 0.020) in the incidence of clinicalmalaria during pregnancy, and reductions in the prevalence of peripheral parasitaemia (7.10% vs 15.15%) (p,0.001), and ofactively infected placentas (7.04% vs 13.60%) (p = 0.002). There was a reduction in severe anaemia at delivery of borderlinestatistical significance (p = 0.055). These effects were not modified by gravidity or HIV status. Reported ITN's use was morethan 90% in both groups.Conclusions:Two-dose SP was associated with a reduction in some indicators, but these were not translated to significantimprovement in other maternal or birth outcomes. The use of ITNs during pregnancy may reduce the need to administerIPTp. ITNs should be part of the ANC package in sub-Saharan Africa
Note: Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0001934
It is part of: PLoS One, 2008, vol. 3, num. 4, p. e1934
Related resource: http://dx.doi.org/10.1371/journal.pone.0001934
URI: http://hdl.handle.net/2445/96004
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Medicina)

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