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Title: Biological convergence of cancer signatures
Author: Solé Acha, Xavier
Bonifaci, Núria
López Bigas, Núria
Berenguer, Antoni
Hernández, Pilar
Reina, Oscar
Maxwell, Christopher A.
Aguilar, Helena
Urruticoechea Ribate, Ander
Sanjosé Llongueras, Silvia de
Comellas, Francesc
Capellá, G. (Gabriel)
Moreno Aguado, Víctor
Pujana Genestar, M. Ángel
Keywords: Càncer
Expressió gènica
Mort cel·lular
Gene expression
Cell death
Issue Date: 20-Feb-2009
Publisher: Public Library of Science (PLoS)
Abstract: Gene expression profiling has identified cancer prognostic and predictive signatures with superior performance to conventional histopathological or clinical parameters. Consequently, signatures are being incorporated into clinical practice and will soon influence everyday decisions in oncology. However, the slight overlap in the gene identity between signatures for the same cancer type or condition raises questions about their biological and clinical implications. To clarify these issues, better understanding of the molecular properties and possible interactions underlying apparently dissimilar signatures is needed. Here, we evaluated whether the signatures of 24 independent studies are related at the genome, transcriptome or proteome levels. Significant associations were consistently observed across these molecular layers, which suggest the existence of a common cancer cell phenotype. Convergence on cell proliferation and death supports the pivotal involvement of these processes in prognosis, metastasis and treatment response. In addition, functional and molecular associations were identified with the immune response in different cancer types and conditions that complement the contribution of cell proliferation and death. Examination of additional, independent, cancer datasets corroborated our observations. This study proposes a comprehensive strategy for interpreting cancer signatures that reveals common design principles and systems-level properties.
Note: Reproducció del document publicat a:
It is part of: PLoS One, 2009, vol. 4, num. 2, p. e4544
Related resource:
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)

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