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http://hdl.handle.net/2445/96085
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DC Field | Value | Language |
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dc.contributor.author | Solé Acha, Xavier | - |
dc.contributor.author | Bonifaci Cano, Núria | - |
dc.contributor.author | López Bigas, Núria | - |
dc.contributor.author | Berenguer, Antoni | - |
dc.contributor.author | Hernández, Pilar | - |
dc.contributor.author | Reina, Oscar | - |
dc.contributor.author | Maxwell, Christopher A. | - |
dc.contributor.author | Aguilar, Helena | - |
dc.contributor.author | Urruticoechea Ribate, Ander | - |
dc.contributor.author | Sanjosé Llongueras, Silvia de | - |
dc.contributor.author | Comellas, Francesc | - |
dc.contributor.author | Capellá, G. (Gabriel) | - |
dc.contributor.author | Moreno Aguado, Víctor | - |
dc.contributor.author | Pujana Genestar, M. Ángel | - |
dc.date.accessioned | 2016-03-03T11:12:01Z | - |
dc.date.available | 2016-03-03T11:12:01Z | - |
dc.date.issued | 2009-02-20 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/96085 | - |
dc.description.abstract | Gene expression profiling has identified cancer prognostic and predictive signatures with superior performance to conventional histopathological or clinical parameters. Consequently, signatures are being incorporated into clinical practice and will soon influence everyday decisions in oncology. However, the slight overlap in the gene identity between signatures for the same cancer type or condition raises questions about their biological and clinical implications. To clarify these issues, better understanding of the molecular properties and possible interactions underlying apparently dissimilar signatures is needed. Here, we evaluated whether the signatures of 24 independent studies are related at the genome, transcriptome or proteome levels. Significant associations were consistently observed across these molecular layers, which suggest the existence of a common cancer cell phenotype. Convergence on cell proliferation and death supports the pivotal involvement of these processes in prognosis, metastasis and treatment response. In addition, functional and molecular associations were identified with the immune response in different cancer types and conditions that complement the contribution of cell proliferation and death. Examination of additional, independent, cancer datasets corroborated our observations. This study proposes a comprehensive strategy for interpreting cancer signatures that reveals common design principles and systems-level properties. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0004544 | - |
dc.relation.ispartof | PLoS One, 2009, vol. 4, num. 2, p. e4544 | - |
dc.relation.uri | http://dx.doi.org/10.1371/journal.pone.0004544 | - |
dc.rights | cc-by (c) Solé, X. et al., 2009 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Càncer | - |
dc.subject.classification | Expressió gènica | - |
dc.subject.classification | Mort cel·lular | - |
dc.subject.classification | Metàstasi | - |
dc.subject.other | Cancer | - |
dc.subject.other | Gene expression | - |
dc.subject.other | Cell death | - |
dc.subject.other | Metastasis | - |
dc.title | Biological convergence of cancer signatures | eng |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 575078 | - |
dc.date.updated | 2016-03-02T07:46:22Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 19229342 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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575078.pdf | 1.29 MB | Adobe PDF | View/Open |
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