Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/96721
Title: Converging Medial Frontal Resting State and Diffusion Based Abnormalities in Borderline Personality Disorder
Author: Salvador, Raymond
Vega, Daniel
Pascual, Juan Carlos
Marco Pallarés, Josep
Canales-Rodriguez, Erick
Aguilar, Salvatore
Anguera, Maria
Soto, Angel
Ribas, Joan
Soler, Joaquim
Maristany, Teresa
Rodríguez Fornells, Antoni
Pomarol-Clotet, Edith
Keywords: Trastorns límits de la personalitat
Imatges per ressonància magnètica
Cervell
Borderline personality disorder
Magnetic resonance imaging
Brain
Issue Date: 16-Sep-2014
Publisher: Elsevier B.V.
Abstract: Background The psychological profile of patients with borderline personality disorder (BPD), with impulsivity and emotional dysregulation as core symptoms, has guided the search for abnormalities in specific brain areas such as the hippocampal-amygdala complex and the frontomedial cortex. However, whole-brain imaging studies so far have delivered highly heterogeneous results involving different brain locations. Methods Functional resting-state and diffusion magnetic resonance imaging data were acquired in patients with BPD and in an equal number of matched control subjects (n = 60 for resting and n = 43 for diffusion). While mean diffusivity and fractional anisotropy brain images were generated from diffusion data, amplitude of low-frequency fluctuations and global brain connectivity images were used for the first time to evaluate BPD-related brain abnormalities from resting functional acquisitions. Results Whole-brain analyses using a p = .05 corrected threshold showed a convergence of alterations in BPD patients in genual and perigenual structures, with frontal white matter fractional anisotropy abnormalities partially encircling areas of increased mean diffusivity and global brain connectivity. Additionally, a cluster of enlarged amplitude of low-frequency fluctuations (high resting activity) was found involving part of the lefthippocampus and amygdala. In turn, this cluster showed increased resting functional connectivity with theanterior cingulate. Conclusions With a multimodal approach and without using a priori selected regions, we prove that structural and functional abnormality in BPD involves both temporolimbic and frontomedial structures as well as their connectivity. These structures have been previously related to behavioral and clinical symptoms in patients with BPD.
Note: Versió postprint del document publicat a: http://dx.doi.org/10.1016/j.biopsych.2014.08.026
It is part of: Biological Psychiatry, 2014, vol. 79, num. 2, p. 107-116
Related resource: http://dx.doi.org/10.1016/j.biopsych.2014.08.026
URI: http://hdl.handle.net/2445/96721
ISSN: 0006-3223
Appears in Collections:Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)

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