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Title: Molecular interplay betweeen cáncer cell fatty acid metabolism and oncogenic signaling as resource for novel treatment strategies against ovarian cancer
Author: Wagner, Renate
Veigel, Daniel
Prostling, K.
Stübiger, Gerald
Grusch, Michael
Weghuber, J.
Singer, C.
Karlic, H.
Colomer, Ramón
López-Rodríguez, María Luz
Benhamú, Bellinda
Hegardt, Fausto
Serra i Cucurull, Dolors
García Gómez, Jordi
Valent, Peter
Grunt, Thomas
Keywords: Trompes de Fal·lopi
Càncer d'ovari
Medicaments antineoplàstics
Àcids grassos
Fallopian tubes
Ovarian cancer
Antineoplastic agents
Fatty acids
Issue Date: 28-Sep-2015
Publisher: Elsevier B.V.
Abstract: The metabolic oncogene fatty acid synthase (FASN) is overexpressed in 80% of ovarian cancers (OC) and indicates poor prognosis. Exposure of OC to inhibitors of FASN elicits a complex stress response that interferes with receptor-PI3K-mTORC1 signaling (briefly designated 'PI3K pathway'). Here we demonstrate that FASN inhibitors capitalize on multiple mechanisms to interfere with the PI3K pathway, and that silencing this cascade is crucial for the anticancer action of the drugs.
Note: Versió postprint del document publicat a:
It is part of: European Journal of Cancer, 2015, vol. 51, num. Supplement 3, p. S49-S49
Related resource:
ISSN: 0959-8049
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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