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Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/97402
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dc.contributor.authorWagner, Renate-
dc.contributor.authorVeigel, Daniel-
dc.contributor.authorProstling, K.-
dc.contributor.authorStübiger, Gerald-
dc.contributor.authorGrusch, Michael-
dc.contributor.authorWeghuber, J.-
dc.contributor.authorSinger, Christian F.-
dc.contributor.authorKarlic, H.-
dc.contributor.authorColomer, Ramón-
dc.contributor.authorLópez-Rodríguez, María Luz-
dc.contributor.authorBenhamú, Bellinda-
dc.contributor.authorHegardt, Fausto-
dc.contributor.authorSerra i Cucurull, Dolors-
dc.contributor.authorGarcía Gómez, Jordi-
dc.contributor.authorValent, Peter-
dc.contributor.authorGrunt, Thomas-
dc.date.accessioned2016-04-14T09:59:33Z-
dc.date.available2016-09-29T22:01:15Z-
dc.date.issued2015-09-28-
dc.identifier.issn0959-8049-
dc.identifier.urihttp://hdl.handle.net/2445/97402-
dc.description.abstractThe metabolic oncogene fatty acid synthase (FASN) is overexpressed in 80% of ovarian cancers (OC) and indicates poor prognosis. Exposure of OC to inhibitors of FASN elicits a complex stress response that interferes with receptor-PI3K-mTORC1 signaling (briefly designated 'PI3K pathway'). Here we demonstrate that FASN inhibitors capitalize on multiple mechanisms to interfere with the PI3K pathway, and that silencing this cascade is crucial for the anticancer action of the drugs.-
dc.format.extent1 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.relation.isformatofVersió postprint del document publicat a: http://dx.doi.org/10.1016/S0959-8049(16)30154-X-
dc.relation.ispartofEuropean Journal of Cancer, 2015, vol. 51, num. Supplement 3, p. S49-S49-
dc.relation.urihttp://dx.doi.org/10.1016/S0959-8049(16)30154-X-
dc.rightscc-by-nc-nd (c) Elsevier B.V., 2015-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es-
dc.sourceArticles publicats en revistes (Química Inorgànica i Orgànica)-
dc.subject.classificationTrompes de Fal·lopi-
dc.subject.classificationCàncer d'ovari-
dc.subject.classificationMedicaments antineoplàstics-
dc.subject.classificationÀcids grassos-
dc.subject.otherFallopian tubes-
dc.subject.otherOvarian cancer-
dc.subject.otherAntineoplastic agents-
dc.subject.otherFatty acids-
dc.titleMolecular interplay betweeen cáncer cell fatty acid metabolism and oncogenic signaling as resource for novel treatment strategies against ovarian cancer-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/acceptedVersion-
dc.identifier.idgrec657043-
dc.date.updated2016-04-14T09:59:39Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
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