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Title: | Differential inhibition of the TGF-b signaling pathway in HCC cells using the small molecule inhibitor LY2157299 and the D10 monoclonal antibody against TGF-β receptor Type II |
Author: | Dituri, Francesco Mazzocca, Antonio Peidrò, Fernando Juan Papappicco, Patrizia Fabregat Romero, Isabel De Santis, Flavia Paradiso, Angelo Sabbà, Carlo Giannelli, Gianluigi |
Keywords: | Anticossos monoclonals Fosforilació Càncer de fetge Factors de creixement Monoclonal antibodies Phosphorylation Liver cancer Growth factors |
Issue Date: | 2013 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | We investigated blocking the TGF-b signaling pathway in HCC using two small molecule inhibitors (LY2157299, LY2109761) and a neutralizing humanized antibody (D10) against TGF-bRII. LY2157299 and LY2109761 inhibited HCC cell migration on Laminin-5, Fibronectin, Vitronectin, Fibrinogen and Collagen-I and de novo phosphorylation of pSMAD2. LY2157299 inhibited HCC migration and cell growth independently of the expression levels of TGF-bRII. In contrast to LY2157299, D10 showed a reduction in pSMAD2 only after a short exposure. This study supports the use of LY2157299 in clinical trials, and presents new insights into TGF-b receptor cycling in cancer cells. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0067109 |
It is part of: | PLoS One, 2013, vol. 8, num. 6, p. e67109 |
URI: | http://hdl.handle.net/2445/97493 |
Related resource: | http://dx.doi.org/10.1371/journal.pone.0067109 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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