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Title: Differential inhibition of the TGF-b signaling pathway in HCC cells using the small molecule inhibitor LY2157299 and the D10 monoclonal antibody against TGF-β receptor Type II
Author: Dituri, Francesco
Mazzocca, Antonio
Peidrò, Fernando Juan
Papappicco, Patrizia
Fabregat Romero, Isabel
De Santis, Flavia
Paradiso, Angelo
Sabbà, Carlo
Giannelli, Gianluigi
Keywords: Anticossos monoclonals
Càncer de fetge
Factors de creixement
Monoclonal antibodies
Liver cancer
Growth factors
Issue Date: 2013
Publisher: Public Library of Science (PLoS)
Abstract: We investigated blocking the TGF-b signaling pathway in HCC using two small molecule inhibitors (LY2157299, LY2109761) and a neutralizing humanized antibody (D10) against TGF-bRII. LY2157299 and LY2109761 inhibited HCC cell migration on Laminin-5, Fibronectin, Vitronectin, Fibrinogen and Collagen-I and de novo phosphorylation of pSMAD2. LY2157299 inhibited HCC migration and cell growth independently of the expression levels of TGF-bRII. In contrast to LY2157299, D10 showed a reduction in pSMAD2 only after a short exposure. This study supports the use of LY2157299 in clinical trials, and presents new insights into TGF-b receptor cycling in cancer cells.
Note: Reproducció del document publicat a:
It is part of: PLoS One, 2013, vol. 8, num. 6, p. e67109
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)

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