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Title: Polμ deficiency increases resistance to oxidative damage and delays liver aging
Author: Escudero, Beatriz
Lucas, Daniel
Albo, Carmen
Dhup, Suveera
Bacher, Jeff W.
Sánchez, Aránzazu
Fernández, Margarita
Rivera Torres, José
Carmona, Rosa M.
Fuster, Encarnación
Carreiro, Candelas
Bernad, Raquel
González, Manuel A.
Andrés, Vicente
Blanco, Luis
Roche, Enrique
Fabregat Romero, Isabel
Samper, Enrique
Bernad, Antonio
Keywords: Apoptosi
Reparació de l'ADN
Estrès oxidatiu
DNA repair
Oxidative stress
Issue Date: Apr-2014
Publisher: Public Library of Science (PLoS)
Abstract: Polμ is an error-prone PolX polymerase that contributes to classical NHEJ DNA repair. Mice lacking Polμ (Polμ−/−) show altered hematopoiesis homeostasis and DSB repair and a more pronounced nucleolytic resection of some V(D)J junctions. We previously showed that Polμ−/− mice have increased learning capacity at old ages, suggesting delayed brain aging. Here we investigated the effect of Polμ−/− deficiency on liver aging. We found that old Polμ−/− mice (>20 month) have greater liver regenerative capacity compared with wt animals. Old Polμ−/− liver showed reduced genomic instability and increased apoptosis resistance. However, Polμ−/− mice did not show an extended life span and other organs (e.g., heart) aged normally. Our results suggest that Polμ deficiency activates transcriptional networks that reduce constitutive apoptosis, leading to enhanced liver repair at old age.
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It is part of: PLoS One, 2014, vol. 9, num. 4, p. e93074
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)

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