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Title: New insights into the crossroads between EMT and stemness in the context of cancer
Author: Fabregat Romero, Isabel
Malfettone, Andrea
Soukupova, J.
Keywords: Factors de creixement
Cèl·lules epitelials
Cèl·lules mare
Growth factors
Epithelial cells
Stem cells
Issue Date: 2016
Publisher: MDPI
Abstract: The epithelial-mesenchymal transition (EMT) is an example of cellular plasticity, where an epithelial cell acquires a mesenchymal-like phenotype that increases its migratory and invasive properties. Stemness is the ability of stem cells to proliferate in an asymmetric way that allows them to maintain the reservoir of undifferentiated cells with stem cell identity, but also to produce new differentiated cells. Initial works revealed that activation of the EMT program in epithelial cells induces the acquisition of stem cell properties, which in the context of cancer may contribute to the appearance of tumor initiating cells (TIC). However, a number of groups have recently reported that mesenchymal-epithelial transition (MET) is required for efficient metastatic colonization and that EMT may be not necessarily associated with stemness. In this review, we summarize recent findings that extend our knowledge about the crossroads between EMT and stemness and their relevance under physiological or pathological conditions.
Note: Reproducció del document publicat a:
It is part of: Journal of Clinical Medicine, 2016, vol. 5, num. 3, p. 37
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ISSN: 2077-0383
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)

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