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Title: Prevalence of methicillin-resistant Staphylococcus aureus colonization in HIV-infected patients in Barcelona, Spain: a cross-sectional study
Author: Imaz, Arkaitz
Camoez, Mariana
Di Yacovo, Silvana
Gasch, Oriol
Domínguez Luzón, Ma. Ángeles (María Ángeles)
Vila, Antonia
Masó Serra, Margarita
Pujol Rojo, Miquel
Podzamczer Palter, Daniel
Keywords: Infeccions nosocomials
Infeccions per VIH
Staphylococcus aureus
Resistència als medicaments
Barcelona (Catalunya : Província)
Nosocomial infections
HIV infections
Staphylococcus aureus
Drug resistance
Barcelona (Catalonia : Province)
Issue Date: 26-Jun-2015
Publisher: BioMed Central
Abstract: Background: Colonization by community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has been found to be markedly more common in HIV-infected individuals in the USA. Studies evaluating the prevalence MRSA colonization in HIV-infected populations in Europe are scarce. The aim of this study was to investigate the prevalence of MRSA colonization in a cohort of HIV-infected patients in Barcelona, Spain. Methods: Nasal and pharyngeal S. aureus carriage was assessed in a random sample of 190 patients from an outpatient HIV clinic. Nasal and pharyngeal swab specimens were obtained for staphylococcal culture from 190 and 110 patients respectively. All MRSA isolates were screened for Panton-Valentine leukocidin (PVL) genes by PCR. Molecular characterization of MRSA isolates was performed by multilocus sequence typing. Data related to HIV infection, healthcare exposure, and previously described risk factors for MRSA were collected from medical records and a questionnaire administered to each patient. Results: The patients' characteristics were as follows: male, 83 %; median (IQR) age, 45 (39-49) years; intravenous drug users, 39 %; men who have sex with men, 32 %; heterosexual, 26 %; CD4 count, 528/μL (IQR 351-740); on antiretroviral therapy, 96 %; and undetectable plasma viral load, 80 %. Sixty-five patients (34 %) were colonized by S. aureus. MRSA colonization was found in 1 % and 2 % of nasal and pharyngeal samples respectively. No PVL positive MRSA strains were detected and all the MRSA isolates belonged to typical hospital-acquired clones. Conclusions: Our data suggest that CA-MRSA colonization is not currently a problem in HIV-infected individuals in our area.
Note: Reproducció del document publicat a:
It is part of: Bmc Infectious Diseases, 2015, vol. 15, p. 1-5
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ISSN: 1471-2334
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)

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