Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/98393
Title: Analysis of the interferon gamma (rs2430561, +874T/A) functional gene variant in relation to the presence of cardiovascular events in rheumatoid arthritis
Author: García Bermúdez, Mercedes
López Mejías, Raquel
González Juanatey, Carlos
Corrales, Alfonso
Robledo, Gema
Castañeda, Santos
Miranda Filloy, José A.
Blanco, Ricardo
Fernández Gutiérrez, Benjamín
Balsa, Alejandro
González Álvaro, Isidoro
Gómez Vaquero, Carmen
Llorca Díaz, Javier
Martín, Javier
González Gay, Miguel A.
Keywords: Artritis reumatoide
Malalties cardiovasculars
Interferó
Rheumatoid arthritis
Cardiovascular diseases
Interferon
Issue Date: 15-Oct-2012
Publisher: Public Library of Science (PLoS)
Abstract: Objective: Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with increased cardiovascular (CV) morbidity and mortality. Since interferon-gamma (IFN-c) has a direct effect on inflammation, in this study we assessed the potential association of the IFNG functional gene variant rs2430561 with CV disease in patients with RA. Methods: One thousand six hundred and thirty-five patients fulfilling the 1987 American College of Rheumatology classification criteria for RA were genotyped for the IFNG (rs2430561, +874T/A) gene polymorphism using TaqMan genotyping assay. Patients were stratified according to the presence of CV events or not. Logistic regression models to explain the presence of CV disease according to the IFNG rs2430561 allele distribution were performed. The potential influence of this variant in the development of subclinical atherosclerosis was also analyzed in a subgroup of patients with no history of CV events to determine carotid artery intima-media thickness (IMT) (n = 286) and presence of carotid plaques. Levels of the cytokine were determined in a subgroup of patients by ELISA. Results: Adjusted logistic regression model disclosed that presence of the minor allele A was not associated with increased risk of suffering CV events in RA patients. Besides, differences did not achieve statistical significance regarding carotid IMT and presence of carotid plaques in RA patients carrying IFNG rs2430561 variant allele. Levels of IFN-c were higher in patients who had suffered CV events compared to patients who did not. Conclusion: Our results do not support a role of IFNG rs2430561 (+874T/A) functional gene variant in the development of CV disease in RA patients.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0047166
It is part of: PLoS One, 2012, vol. 7, num. 10, p. e47166
Related resource: http://dx.doi.org/10.1371/journal.pone.0047166
URI: http://hdl.handle.net/2445/98393
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)

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