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Title: Inflammation and Obesity (Lipoinflammation)
Author: Izaola, Olatz
Luis, Daniel de
Sajoux, Ignacio
Domingo i Pedrol, Joan Carles
Vidal, Montserrat
Keywords: Obesitat
Issue Date: 1-Jun-2015
Publisher: Aula Médica
Abstract: Obesity is a chronic disease with multiple origins. It is a widespread global phenomenon carrying potentially serious complications which requires a multidisciplinary approach due to the significant clinical repercussions and elevated health costs associated with the disease. The most recent evidence indicates that it shares a common characteristic with other prevalent, difficult-to-treat pathologies: chronic, low-grade inflammation which perpetuates the disease and is associated with multiple complications. The current interest in lipoinflammation or chronic inflammation associated with obesity derives from an understanding of the alterations and remodelling that occurs in the adipose tissue, with the participation of multiple factors and elements throughout the process. Recent research highlights the importance of some of these molecules, called pro-resolving mediators, as possible therapeutic targets in the treatment of obesity. This article reviews the evidence published on the mechanisms that regulate the adipose tissue remodelling process and lipoinflammation both in obesity and in the mediators that are directly involved in the appearance and resolution of the inflammatory process.
Note: Reproducció del document publicat a:
It is part of: Nutrición Hospitalaria, 2015, vol. 31, num. 6, p. 2352-2358
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ISSN: 0212-1611
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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