Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/98520
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cubero, Meritxell | - |
dc.contributor.author | Cuervo Requena, Guillermo | - |
dc.contributor.author | Domínguez Luzón, Ma. Ángeles (María Ángeles) | - |
dc.contributor.author | Tubau, Fe | - |
dc.contributor.author | Martí Martí, Sara | - |
dc.contributor.author | Sevillano, Elena | - |
dc.contributor.author | Gallego, Lucía | - |
dc.contributor.author | Ayats, Josefina | - |
dc.contributor.author | Peña Miralles, Carmen | - |
dc.contributor.author | Pujol Rojo, Miquel | - |
dc.contributor.author | Liñares Louzao, Josefina | - |
dc.contributor.author | Ardanuy Tisaire, María Carmen | - |
dc.date.accessioned | 2016-05-11T12:26:17Z | - |
dc.date.available | 2016-05-11T12:26:17Z | - |
dc.date.issued | 2015-09-03 | - |
dc.identifier.issn | 1471-2180 | - |
dc.identifier.uri | http://hdl.handle.net/2445/98520 | - |
dc.description.abstract | Background: In this study we describe the clinical and molecular characteristics of an outbreak due to carbapenem-resistant Klebsiella pneumoniae (CR-KP) producing CTX-M-15 and OXA-48 carbapenemase. Isogenic strains, carbapenem-susceptible K. pneumoniae (CS-KP) producing CTX-M-15, were also involved in the outbreak. Results: From October 2010 to December 2012 a total of 62 CR-KP and 23 CS-KP were isolated from clinical samples of 42 patients (22 had resistant isolates, 14 had susceptible isolates, and 6 had both CR and CS isolates). All patients had underlying diseases and 17 of them (14 patients with CR-KP and 3 with CS-KP) had received carbapenems previously. The range of carbapenem MICs for total isolates were: imipenem: 2 to >32 μg/ml vs. <2 μg/ml; meropenem: 4 to >32 μg/ml vs. <2 μg/ml; and ertapenem: 8 to >32 μg/ml vs. <2 μg/ml. All the isolates were also resistant to gentamicin, ciprofloxacin, and cotrimoxazole. Both types of isolates shared a common PFGE pattern associated with the multilocus sequence type 101 (ST101). The blaCTX-M-15 gene was detected in all the isolates, whereas the bla OXA-48 gene was only detected in CR-KP isolates on a 70 kb plasmid. Conclusions: The clonal spread of K. pneumoniae ST101 expressing the OXA-48 and CTX-M-15 beta-lactamases was the cause of an outbreak of CR-KP infections. CTX-M-15-producing isolates lacking the bla OXA-48 gene coexisted during the outbreak. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1186/s12866-015-0510-9 | - |
dc.relation.ispartof | BMC Microbiology, 2015, vol. 15, p. 177 | - |
dc.relation.uri | http://dx.doi.org/10.1186/s12866-015-0510-9 | - |
dc.rights | cc-by (c) Cubero, Meritxell et al., 2015 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Patologia i Terapèutica Experimental) | - |
dc.subject.classification | Antibiòtics betalactàmics | - |
dc.subject.classification | Klebsiella pneumoniae | - |
dc.subject.classification | Resistència als medicaments | - |
dc.subject.classification | Medicaments antibacterians | - |
dc.subject.classification | Infeccions | - |
dc.subject.classification | Hospitals | - |
dc.subject.other | Beta lactam antibiotics | - |
dc.subject.other | Klebsiella pneumoniae | - |
dc.subject.other | Drug resistance | - |
dc.subject.other | Antibacterial agents | - |
dc.subject.other | Infections | - |
dc.subject.other | Hospitals | - |
dc.title | Carbapenem-resistant and carbapenem-susceptible isogenic isolates of Klebsiella pneumoniae ST101 causing infection in a tertiary hospital | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 661748 | - |
dc.date.updated | 2016-05-11T12:26:23Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26335352 | - |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
661748.pdf | 839.54 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License