Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/98663
Title: Marine organism sulfated polysaccharides exhibiting significant antimalarial activity and inhibition of red blood cell invasion by Plasmodium
Author: Marques, J.
Vilanova, E.
Mourao, P. A. S.
Fernàndez Busquets, Xavier
Keywords: Polisacàrids
Ratolins (Animals de laboratori)
Polysaccharides
Mice (Laboratory animals)
Issue Date: 13-Apr-2016
Publisher: Nature Publishing Group
Abstract: The antimalarial activity of heparin, against which there are no resistances known, has not been therapeutically exploited due to its potent anticoagulating activity. Here, we have explored the antiplasmodial capacity of heparin-like sulfated polysaccharides from the sea cucumbers Ludwigothurea grisea and Isostichopus badionotus, from the red alga Botryocladia occidentalis, and from the marine sponge Desmapsamma anchorata. In vitro experiments demonstrated for most compounds significant inhibition of Plasmodium falciparum growth at low-anticoagulant concentrations. This activity was found to operate through inhibition of erythrocyte invasion by Plasmodium, likely mediated by a coating of the parasite similar to that observed for heparin. In vivo four-day suppressive tests showed that several of the sulfated polysaccharides improved the survival of Plasmodium yoelii-infected mice. In one animal treated with I. badionotus fucan parasitemia was reduced from 10.4% to undetectable levels, and Western blot analysis revealed the presence of antibodies against P. yoelii antigens in its plasma. The retarded invasion mediated by sulfated polysaccharides, and the ensuing prolonged exposure of Plasmodium to the immune system, can be explored for the design of new therapeutic approaches against malaria where heparin-related polysaccharides of low anticoagulating activity could play a dual role as drugs and as potentiators of immune responses.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1038/srep24368
It is part of: Scientific Reports, 2016, num. 6 , p. 1-14
Related resource: http://dx.doi.org/10.1038/srep24368
URI: http://hdl.handle.net/2445/98663
ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (ISGlobal)

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