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|Title:||Absence of hepatitis delta infection in a large rural HIV cohort in Tanzania|
Kalinjuma, Aneth Vedastus
Ntamatungiro, Alex J.
Glass, T. R.
Le Gal, F.
KIULARCO Study Group
Virus de l'hepatitis delta
Hepatitis D (hepatitis delta)
|Abstract:||OBJECTIVES: The epidemiological and clinical determinants of hepatitis delta virus (HDV) infection in Sub-Saharan Africa are ill-defined. The prevalence of HDV infection was determined in HIV/hepatitis B virus (HBV) co-infected individuals in rural Tanzania. METHODS: All hepatitis B virus (HBV)-infected adults under active follow-up in the Kilombero and Ulanga Antiretroviral Cohort (KIULARCO) were screened for anti-HDV antibodies. For positive samples, a second serological test and nucleic acid amplification were performed. Demographic and clinical characteristics at initiation of antiretroviral therapy (ART) were compared between anti-HDV-negative and positive patients. RESULTS: Among 222 HIV/HBV co-infected patients on ART, 219 (98.6%) had a stored serum sample available and were included in the study. Median age was 37 years, 55% were female, 46% had World Health Organization stage III/IV HIV disease, and the median CD4 count was 179 cells/mul. The prevalence of anti-HDV positivity was 5.0% (95% confidence interval 2.8-8.9%). There was no significant predictor of anti-HDV positivity. HDV could not be amplified in any of the anti-HDV-positive patients and the second serological test was negative in all of them. CONCLUSIONS: No confirmed case of HDV infection was found among over 200 HIV/HBV co-infected patients in Tanzania. As false-positive serology results are common, screening results should be confirmed with a second test.|
|Note:||Reproducció del document publicat a: http://dx.doi.org/10.1016/j.ijid.2016.03.011|
|It is part of:||International Journal of Infectious Diseases, 2016, vol. 46, p. 8-10|
|Appears in Collections:||Articles publicats en revistes (ISGlobal)|
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