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Title: | Absence of hepatitis delta infection in a large rural HIV cohort in Tanzania |
Author: | Winter, Annja Letang, Emilio Kalinjuma, Aneth Vedastus Kimera, Namvua Ntamatungiro, Alex J. Glass, Tracy R. Moradpour, Darius Sahli, Roland Le Gal, Frédéric Furrer, Hansjakob Wandeler, Gilles KIULARCO Study Group |
Keywords: | VIH (Virus) Virus de l'hepatitis delta HIV (Viruses) Hepatitis D (hepatitis delta) |
Issue Date: | May-2016 |
Publisher: | Elsevier Inc. |
Abstract: | OBJECTIVES: The epidemiological and clinical determinants of hepatitis delta virus (HDV) infection in Sub-Saharan Africa are ill-defined. The prevalence of HDV infection was determined in HIV/hepatitis B virus (HBV) co-infected individuals in rural Tanzania. METHODS: All hepatitis B virus (HBV)-infected adults under active follow-up in the Kilombero and Ulanga Antiretroviral Cohort (KIULARCO) were screened for anti-HDV antibodies. For positive samples, a second serological test and nucleic acid amplification were performed. Demographic and clinical characteristics at initiation of antiretroviral therapy (ART) were compared between anti-HDV-negative and positive patients. RESULTS: Among 222 HIV/HBV co-infected patients on ART, 219 (98.6%) had a stored serum sample available and were included in the study. Median age was 37 years, 55% were female, 46% had World Health Organization stage III/IV HIV disease, and the median CD4 count was 179 cells/mul. The prevalence of anti-HDV positivity was 5.0% (95% confidence interval 2.8-8.9%). There was no significant predictor of anti-HDV positivity. HDV could not be amplified in any of the anti-HDV-positive patients and the second serological test was negative in all of them. CONCLUSIONS: No confirmed case of HDV infection was found among over 200 HIV/HBV co-infected patients in Tanzania. As false-positive serology results are common, screening results should be confirmed with a second test. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1016/j.ijid.2016.03.011 |
It is part of: | International Journal of Infectious Diseases, 2016, vol. 46, p. 8-10 |
URI: | http://hdl.handle.net/2445/98687 |
Related resource: | http://dx.doi.org/10.1016/j.ijid.2016.03.011 |
ISSN: | 1201-9712 |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
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