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DC Field | Value | Language |
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dc.contributor.author | Winter, Annja | - |
dc.contributor.author | Letang, Emilio | - |
dc.contributor.author | Kalinjuma, Aneth Vedastus | - |
dc.contributor.author | Kimera, Namvua | - |
dc.contributor.author | Ntamatungiro, Alex J. | - |
dc.contributor.author | Glass, Tracy R. | - |
dc.contributor.author | Moradpour, Darius | - |
dc.contributor.author | Sahli, Roland | - |
dc.contributor.author | Le Gal, Frédéric | - |
dc.contributor.author | Furrer, Hansjakob | - |
dc.contributor.author | Wandeler, Gilles | - |
dc.contributor.author | KIULARCO Study Group | - |
dc.date.accessioned | 2016-05-19T11:05:01Z | - |
dc.date.available | 2016-05-19T11:05:01Z | - |
dc.date.issued | 2016-05 | - |
dc.identifier.issn | 1201-9712 | - |
dc.identifier.uri | http://hdl.handle.net/2445/98687 | - |
dc.description.abstract | OBJECTIVES: The epidemiological and clinical determinants of hepatitis delta virus (HDV) infection in Sub-Saharan Africa are ill-defined. The prevalence of HDV infection was determined in HIV/hepatitis B virus (HBV) co-infected individuals in rural Tanzania. METHODS: All hepatitis B virus (HBV)-infected adults under active follow-up in the Kilombero and Ulanga Antiretroviral Cohort (KIULARCO) were screened for anti-HDV antibodies. For positive samples, a second serological test and nucleic acid amplification were performed. Demographic and clinical characteristics at initiation of antiretroviral therapy (ART) were compared between anti-HDV-negative and positive patients. RESULTS: Among 222 HIV/HBV co-infected patients on ART, 219 (98.6%) had a stored serum sample available and were included in the study. Median age was 37 years, 55% were female, 46% had World Health Organization stage III/IV HIV disease, and the median CD4 count was 179 cells/mul. The prevalence of anti-HDV positivity was 5.0% (95% confidence interval 2.8-8.9%). There was no significant predictor of anti-HDV positivity. HDV could not be amplified in any of the anti-HDV-positive patients and the second serological test was negative in all of them. CONCLUSIONS: No confirmed case of HDV infection was found among over 200 HIV/HBV co-infected patients in Tanzania. As false-positive serology results are common, screening results should be confirmed with a second test. | - |
dc.format.extent | 3 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Inc. | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1016/j.ijid.2016.03.011 | - |
dc.relation.ispartof | International Journal of Infectious Diseases, 2016, vol. 46, p. 8-10 | - |
dc.relation.uri | http://dx.doi.org/10.1016/j.ijid.2016.03.011 | - |
dc.rights | cc by-nc-nd (c) Winter et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | - |
dc.source | Articles publicats en revistes (ISGlobal) | - |
dc.subject.classification | VIH (Virus) | - |
dc.subject.classification | Virus de l'hepatitis delta | - |
dc.subject.other | HIV (Viruses) | - |
dc.subject.other | Hepatitis D (hepatitis delta) | - |
dc.title | Absence of hepatitis delta infection in a large rural HIV cohort in Tanzania | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2016-05-10T15:02:08Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26996457 | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
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File | Description | Size | Format | |
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PIIS1201971216309985.pdf | 266.94 kB | Adobe PDF | View/Open |
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