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Title: Synthesis of (E)-4-bromo-3-methoxybut-3-en-2-one, the key fragment in the polyhydroxylated chain common to oscillariolide and phormidolides A-C
Author: Gil, Alejandro
Lamariano Merketegi, Janire
Lorente Crivillé, Adriana
Albericio Palomera, Fernando
Álvarez Domingo, Mercedes
Keywords: Productes naturals
Síntesi asimètrica
Química orgànica
Natural products
Asymmetric synthesis
Organic chemistry
Issue Date: 17-May-2016
Publisher: Wiley-VCH
Abstract: The terminal bromomethoxydiene (BMD) moiety of the polyhydroxylated chain present in phormidolides and oscillariolides has been synthesized for first time. Several strategies for the stereoselective synthesis of the 4-bromo-3-methoxybut-3-en-2-ones are described. Furthermore, a preliminary study to successfully introduce this fragment within the polyol chain and introduction of the fatty acid allowed corroborate the end structure of the polyol.
Note: Versió postprint del document publicat a:
It is part of: Chemistry-A European Journal, 2016, vol. 22, num. 21, p. 7033-7035
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ISSN: 0947-6539
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
Articles publicats en revistes (Química Inorgànica i Orgànica)

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