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Issue Date	Title	Author(s)
16-Feb-2024	Chemical rewiring of ubiquitination by degraders and their selectivity routes	Whelan, Rory; Mayor-Ruiz, Cristina
17-Nov-2023	Targeted protein degradation: Proximity-inducing pharmacology	Winter GE; Mayor-Ruiz C
28-Aug-2023	Domain collapse and active site ablation generate a widespread animal mitochondrial seryl-tRNA synthetase	de Potter, B.; Vallee, I.; Camacho, N.; Filipe Costa Póvoas, L.; Bonsembiante, A.; Pons I Pons, A.; Eckhard, U.; Gomis Rüth, F. X.; Yang, X. L.; Schimmel, P.; Kuhle, B.; Ribas de Pouplana, L.
28-Dec-2023	Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders.	Barbosa, Bárbara M. G.; Sfyaki, Aikaterini; Rafael, Sergi; José-Duran, Ferran; Pous, Joan; Sánchez Zarzalejo, Carolina; Perez-Lopez, Carles; Vilanova, Mar; Cigler, Marko; Gay, Marina; Vilaseca, Marta; Winter, Georg E.; Riera i Escalé, Antoni; Mayor-Ruiz, Cristina
Mar-2024	Mitofusin-2 induced by exercise modifies lipid droplet-mitochondria communication, promoting fatty acid oxidation in male mice with NAFLD	Bórquez, Juan Carlos; Díaz-Castro, Francisco; Pino-de La Fuente, Francisco; Espinoza, Karla; Figueroa, Ana María; Martínez-Ruiz, Inma; Hernández, Vanessa; López-Soldado, Iiana; Ventura, Raúl; Domingo i Pedrol, Joan Carles; Bosch i Rodríguez, Marta; Fajardo, Alba; Sebastián Muñoz, David; Espinosa, Alejandra; Pol i Sorolla, Albert; Zorzano Olarte, Antonio; Cortés, Víctor; Hernández-Alvarez, María Isabel; Troncoso, Rodrigo
5-Feb-2020	Pathway and network analysis of more than 2500 whole cancer genomes	Reyna, Matthew A.; Haan, David; Paczkowska, Marta; Verbeke, Lieven P. C.; Vazquez, Miguel; Kahraman, Abdullah; Pulido-Tamayo, Sergio; Barenboim, Jonathan; Wadi, Lina; Dhingra, Priyanka; Shrestha, Raunak; Getz, Gad; Lawrence, Michael S.; Pedersen, Jakob Skou; Rubin, Mark A.; Wheeler, David A.; Brunak, Søren; Izarzugaza, Jose M. G.; Khurana, Ekta; Marchal, Kathleen; von Mering, Christian; Sahinalp, S. Cenk; Valencia, Alfonso; PCAWG Drivers and Functional Interpretation Working Group; Reimand, Jüri; Stuart, Joshua M.; Raphael, Benjamin J.; PCAWG Consortium; Deu-Pons, Jordi; Frigola, Joan; Gonzalez-Perez, Abel; Muiños, Ferran; Mularoni, Loris; Pich, Oriol; Reyes-Salazar, Iker; Rubio-Perez, Carlota; Sabarinathan, Radhakrishnan; Tamborero, David; Aymerich Gregorio, Marta; Campo Güerri, Elias; López Guillermo, Armando; Gelpi Buchaca, Josep Lluís; Rabionet Janssen, Raquel
5-Feb-2020	Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig	Rubanova, Yulia; Shi, Ruian; Harrigan, Caitlin F.; Li, Roujia; Wintersinger, Jeff; Sahin, Nil; Deshwar, Amit G.; PCAWG Evolution and Heterogeneity Working Group; Morris, Quaid D.; PCAWG Consortium; Deu-Pons, Jordi; Frigola, Joan; Gonzalez-Perez, Abel; Muiños, Ferran; Mularoni, Loris; Pich, Oriol; Reyes-Salazar, Iker; Rubio-Perez, Carlota; Sabarinathan, Radhakrishnan; Tamborero, David; Aymerich Gregorio, Marta; Campo Güerri, Elias; López Guillermo, Armando; Gelpi Buchaca, Josep Lluís; Rabionet Janssen, Raquel
5-Feb-2020	A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns	Jiao, Wei; Atwal, Gurnit; Polak, Paz; Karlic, Rosa; Cuppen, Edwin; PCAWG Tumor Subtypes and Clinical Translation Working Group; Danyi, Alexandra; de Ridder, Jeroen; van Herpen, Carla; Lolkema, Martijn P.; Steeghs, Neeltje; Getz, Gat; Morris, Quaid D.; Stein, Lincoln D.; PCAWG Consortium; Deu-Pons, Jordi; Frigola, Joan; Gonzalez-Perez, Abel; Muiños, Ferran; Mularoni, Loris; Pich, Oriol; Reyes-Salazar, Iker; Rubio-Perez, Carlota; Sabarinathan, Radhakrishnan; Tamborero, David; Aymerich Gregorio, Marta; Campo Güerri, Elias; López Guillermo, Armando; Gelpi Buchaca, Josep Lluís; Rabionet Janssen, Raquel
15-Jul-2023	EvolClustDB: Exploring Eukaryotic Gene Clusters with Evolutionarily Conserved Genomic Neighbourhoods	Marcet Houben, M.; Collado Cala, I.; Fuentes Palacios, D.; Gómez, A. D.; Molina, M.; Garisoain Zafra, A.; Chorostecki, U.; Gabaldon, T.
7-Dec-2021	Structural basis for substrate specificity of heteromeric transporters of neutral amino acids	Rodriguez, Carlos F.; Escudero-Bravo, Paloma; Díaz, Lucía; Bartoccioni, Paola; Martín García, Carmen; Gilabert, Joan G.; Boskovic, Jasminka; Guallar i Tasies, Víctor; Errasti-Murugarren, Ekaitz; Llorca, Oscar; Palacín Prieto, Manuel
5-Feb-2020	Combined burden and functional impact tests for cancer driver discovery using DriverPower	Shuai, Shimin; PCAWG Drivers and Functional Interpretation Working Group; Gallinger, Steven; Stein, Lincoln D.; PCAWG Consortium; Deu-Pons, Jordi; Frigola, Joan; Gonzalez-Perez, Abel; Muiños, Ferran; Mularoni, Loris; Pich, Oriol; Reyes-Salazar, Iker; Rubio-Perez, Carlota; Sabarinathan, Radhakrishnan; Tamborero, David; Aymerich Gregorio, Marta; Campo Güerri, Elias; López Guillermo, Armando; Gelpi Buchaca, Josep Lluís; Rabionet Janssen, Raquel
5-Feb-2020	Divergent mutational processes distinguish hypoxic and normoxic tumours	Bhandari, Vinayak; Li, Constance H.; Bristow, Robert G.; Boutros, Paul C.; PCAWG Consortium; Deu-Pons, Jordi; Frigola, Joan; Gonzalez-Perez, Abel; Muiños, Ferran; Mularoni, Loris; Pich, Oriol; Reyes-Salazar, Iker; Rubio-Perez, Carlota; Sabarinathan, Radhakrishnan; Tamborero, David; Aymerich Gregorio, Marta; Gelpi Buchaca, Josep Lluís; López Guillermo, Armando; Rabionet Janssen, Raquel; Campo Güerri, Elias
5-Feb-2020	Integrative pathway enrichment analysis of multivariate omics data	Paczkowska, Marta; Barenboim, Jonathan; Sintupisut, Nardnisa; Fox, Natalie S.; Zhu, Helen; Abd-Rabbo, Diala; Mee, Miles W.; Boutros, Paul C.; Deu-Pons, Jordi; Frigola, Joan; Gonzalez-Perez, Abel; Muiños, Ferran; Mularoni, Loris; Pich, Oriol; Reyes-Salazar, Iker; Rubio-Perez, Carlota; Sabarinathan, Radhakrishnan; Tamborero, David; PCAWG Drivers and Functional Interpretation Working Group; Reimand, Jüri; PCAWG Consortium; Aymerich Gregorio, Marta; Campo Güerri, Elias; López Guillermo, Armando; Gelpi Buchaca, Josep Lluís; Rabionet Janssen, Raquel
24-Jan-2024	The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2	Chaib, S.; López Domínguez, J. A.; Lalinde Gutiérrez, M.; Prats, N.; Marin, I.; Boix, O.; Garcia Garijo, A.; Meyer, K.; Muñoz, M. I.; Aguilera, M.; Mateo, L.; Stephan Otto Attolini, C.; Llanos, S.; Pérez Ramos, S.; Escorihuela, M.; Al Shahrour, F.; Cash, T. P.; Tchkonia, T.; Kirkland, J. L.; Abad, M.; Gros, A.; Arribas, J.; Serrano, M.
11-Jan-2024	Interleukin-6-elicited chronic neuroinflammation may decrease survival but is not sufficient to drive disease progression in a mouse model of Leigh syndrome	Aguilar, Kevin; Canal, Carla; Comes, Gemma; Diaz Clavero, Sandra; Llanos, Maria Angeles; Quintana, Albert; Sanz, Elisenda; Hidalgo, Juan
30-Jan-2023	MmCMS: mouse models' consensus molecular subtypes of colorectal cancer	Amirkhah, Raheleh; Gilroy, Kathryn; Malla, Sudhir B.; Lannagan, Tamsin R. M.; Byrne, Ryan M,; Fisher, Natalie C.; Corry, Shania M.; Mohamed, Noha-Ehssan; Naderi-Meshkin, Hojjat; Mills, Megan L.; Campbell, Andrew D.; Ridgeway, Rachel A.; Ahmaderaghi, Baharak; Murray, Richard; Berenguer Llergo, Antoni; Sanz Pamplona, Rebeca; Villanueva Garatachea, Alberto; Batlle, Eduard; Salazar Soler, Ramón; Lawler, Mark; Sansom, Owen J.; Dunne, Philip D.
16-Jun-2023	Proton and alpha radiation-induced mutational profiles in human cells	Delhomme, T. M.; Munteanu, M.; Buonanno, M.; Grilj, V.; Biayna, J.; Supek, F.
11-Apr-2023	Correlated motions in DNA. Beyond base-pair step models of DNA flexibility	López-Güell, Kim; Battistini, Federica; Orozco López, Modesto
15-Mar-2023	Antitumor T‐cell function requires CPEB4‐mediated adaptation to chronic endoplasmic reticulum stress	Fernández Alfara, Marcos; Sibilio, Annarita; Martín, Judit; Tusquets Uxó, Elsa; Malumbres, Marcos; Alcalde, Victor; Chanes, Verónica; Cañellas Socias, Adrià; Palomo Ponce, Sergio; Batlle, Eduard; Méndez, Raul
10-Jan-2024	Cell cycle gene alterations associate with a redistribution of mutation risk across chromosomal domains in human cancers	Salvadores, Marina; Supek, Fran

Recent Submissions

Chemical rewiring of ubiquitination by degraders and their selectivity routes

Targeted protein degradation: Proximity-inducing pharmacology

Domain collapse and active site ablation generate a widespread animal mitochondrial seryl-tRNA synthetase

Discovery and Mechanistic Elucidation of NQO1-Bioactivatable Small Molecules That Overcome Resistance to Degraders.

Mitofusin-2 induced by exercise modifies lipid droplet-mitochondria communication, promoting fatty acid oxidation in male mice with NAFLD