Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/98965
Title: Aspirin in the 21st century-common mechanisms of disease and their modulation by aspirin: a report from the 2015 scientific conference of the international aspirin foundation, 28 August, London, UK.
Author: Smith, T.
Hutchison, P.
Schrör, K.
Clària i Enrich, Joan
Lanas, A.
Patrignani, P.
Chan, A. T.
Din, F.
Langley R.
Elwood, P.
Freedman, A.
Eccles, R.
Keywords: Aspirina
Càncer
Diabetis
VIH (Virus)
Aspirin
Cancer
Diabetes
HIV (Viruses)
Issue Date: 13-Oct-2015
Publisher: Cancer Intelligence
Abstract: Professor Peter Rothwell of Oxford University chaired the annual Scientific Conference of the International Aspirin Foundation in London on 28 August 2015. It took the form of four sessions. Aspirin has more than one action in its effects on disease. Its acetylation of cyclooxygenase 2 (COX-2) in platelets leads to the blockade of pro-inflammatory chemicals and generation of anti-inflammatory mediators and increase in nitrous oxide (NO) production, which helps to preserve arterial endothelium. But platelets are not its only target. There is now evidence that aspirin has a direct antitumour effect on intestinal mucosal cells that block their potential transformation into cancer cells. Randomised placebo-controlled trials (RCTs) in people with histories of colorectal neoplasia have shown that aspirin reduces the risk of recurrent adenomas and reduces long-term cancer incidence in patients with Lynch syndrome. Among women given aspirin for cardiovascular disease, there were fewer cancers than in those given placebo. Epidemiological evidence has suggested that aspirin treatment after cancer is diagnosed reduces the incidence of metastases and prolongs survival, and long-term studies of anticancer treatment with aspirin are under way to confirm this. Apart from cancer studies, aspirin use is now firmly established as treatment for antiphospholipid syndrome (Hughes syndrome) and is being used to prevent and treat the heightened risk of cardiovascular disease in diabetes mellitus and in patients with HIV.
Note: Reproducció del document publicat a: http://dx.doi.org/10.3332/ecancer.2015.581
It is part of: Ecancermedicalscience, 2015, vol. 9, num. 581
Related resource: http://dx.doi.org/10.3332/ecancer.2015.581
URI: http://hdl.handle.net/2445/98965
ISSN: 1754-6605
Appears in Collections:Articles publicats en revistes (Biomedicina)

Files in This Item:
File Description SizeFormat 
660656.pdf320 kBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons