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Title: Enantioselective total synthesis of fluvirucinin B1
Author: Guignard, Guillaume
Llor Brunés, Núria
Molins i Grau, Elies
Bosch Cartes, Joan
Amat Tusón, Mercedes
Keywords: Síntesi orgànica
Organic synthesis
Issue Date: 15-Apr-2016
Publisher: American Chemical Society
Abstract: A convergent synthesis of fluvirucinin B1 from acid ent-6a and nitrile ent-9, involving an organocopper coupling, a stereoselective allylation, a ring-closing metathesis reaction, and a stereoselective hydrogenation as the key steps, is reported. The starting building blocks have been prepared in a straightforward manner from a common phenylglycinol-derived lactam 1. An unprecedented regioselective oxidation of phenylglycinol-derived secondary amines 5 to carboxylic acids 6 has been developed.
Note: Versió postprint del document publicat a:
It is part of: Organic Letters, 2016, vol. 18, num. 81, p. 1788-1791
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ISSN: 1523-7060
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

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