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Title: Genomic Analyses across Six Cancer Types Identify Basal-like Breast Cancer as a Unique Molecular Entity
Author: Prat Aparicio, Aleix
Adamo, Barbara
Fan, Cheng
Peg, Vincent
Vidal, Maria
Galván, Patricia
Vivancos, Ana
Nuciforo, Paolo
Palmer, Héctor G.
Dawood, Shaheenah
Rodón, Jordi
Ramón y Cajal Agüeras, Santiago
Campo, Josep Maria
Felip, Enriqueta
Tabernero, Josep
Cortés Javier
Keywords: Genòmica
Marcadors bioquímics
Assaigs clínics
Biochemical markers
Clinical trials
Issue Date: 18-Dec-2013
Publisher: Nature Publishing Group
Abstract: To improve our understanding of the biological relationships among different types of cancer, we have characterized variation in gene expression patterns in a set of 1,707 samples representing 6 human cancer types (breast, ovarian, brain, colorectal, lung adenocarcinoma and squamous cell lung cancer). In the unified dataset, breast tumors of the Basal-like subtype were found to represent a unique molecular entity as any other cancer type, including the rest of breast tumors, while showing striking similarities with squamous cell lung cancers. Moreover, gene signatures tracking various cancer- and stromal-related biological processes such as proliferation, hypoxia and immune activation were found expressed similarly in different proportions of tumors across the various cancer types. These data suggest that clinical trials focusing on tumors with common profiles and/or biomarker expression rather than their tissue of origin are warranted with a special focus on Basal-like breast cancer and squamous cell lung carcinoma.
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It is part of: Scientific Reports, 2013, vol. 3, num. 3544
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Medicina)

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