Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/99123
Title: Genomic Analyses across Six Cancer Types Identify Basal-like Breast Cancer as a Unique Molecular Entity
Author: Prat Aparicio, Aleix
Adamo, Barbara
Fan, Cheng
Peg, V.
Vidal, Maria
Galván, P.
Vivancos, Ana
Nuciforo, P.
Palmer, H.G.
Dawood, S,
Rodón, J.
Ramón y Cajal Agüeras, Santiago
Campo, J.M.
Felip, Enriqueta
Tabernero, J.
Cortés J.
Keywords: Genòmica
Càncer
Marcadors bioquímics
Assaigs clínics
Oncologia
Genomics
Cancer
Biochemical markers
Clinical trials
Oncology
Issue Date: 18-Dec-2013
Publisher: Nature Publishing Group
Abstract: To improve our understanding of the biological relationships among different types of cancer, we have characterized variation in gene expression patterns in a set of 1,707 samples representing 6 human cancer types (breast, ovarian, brain, colorectal, lung adenocarcinoma and squamous cell lung cancer). In the unified dataset, breast tumors of the Basal-like subtype were found to represent a unique molecular entity as any other cancer type, including the rest of breast tumors, while showing striking similarities with squamous cell lung cancers. Moreover, gene signatures tracking various cancer- and stromal-related biological processes such as proliferation, hypoxia and immune activation were found expressed similarly in different proportions of tumors across the various cancer types. These data suggest that clinical trials focusing on tumors with common profiles and/or biomarker expression rather than their tissue of origin are warranted with a special focus on Basal-like breast cancer and squamous cell lung carcinoma.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1038/srep03544
It is part of: Scientific Reports, 2013, vol. 3, num. 3544
Related resource: http://dx.doi.org/10.1038/srep03544
URI: http://hdl.handle.net/2445/99123
ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Medicina)

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